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MedKoo Cat#: 125971 | Name: Dimethylamiloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimethylamiloride is a Na(+)-H+ exchange inhibitor.

Chemical Structure

Dimethylamiloride
CAS#1214-79-5 (free base)

Theoretical Analysis

MedKoo Cat#: 125971

Name: Dimethylamiloride

CAS#: 1214-79-5 (free base)

Chemical Formula: C8H12ClN7O

Exact Mass: 257.0792

Molecular Weight: 257.68

Elemental Analysis: C, 37.29; H, 4.69; Cl, 13.76; N, 38.05; O, 6.21

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
2235-97-4 (HCl) 1214-79-5 (free base)
Synonym
5-dimethylamiloride; dimethylamiloride; 1214-79-5; MK 685; MK-685; 5-(N,N)-Dimethylamiloride
IUPAC/Chemical Name
3-amino-N-carbamimidoyl-6-chloro-5-(dimethylamino)pyrazine-2-carboxamide
InChi Key
RXMUPNVSYKGKMY-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H12ClN7O/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12/h1-2H3,(H2,10,14)(H4,11,12,15,17)
SMILES Code
CN(C)C1=NC(N)=C(N=C1Cl)C(=O)NC(N)=N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 257.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li YY, Liang NC, Jiang L, Wu T, Lin XY. Dimethylamiloride-induced differentiation of HL-60 cells. Acta Pharmacol Sin. 2000 May;21(5):445-9. PMID: 11324444. 2: Zerbini G, Mangili R, Pozza G. Independence of dimethylamiloride-sensitive Li+ efflux pathways and Na+-Li+ countertransport in human erythrocytes. Biochim Biophys Acta. 1998 Apr 22;1371(1):129-33. doi: 10.1016/s0005-2736(98)00012-1. PMID: 9565666. 3: Marina Prendes MG, García JV, Testoni G, Fernández MA, Perazzo JC, Savino EA, Varela A. Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts. Arch Physiol Biochem. 2006 Feb;112(1):31-6. doi: 10.1080/13813450500500357. PMID: 16754201. 4: Prendes MG, Torresín E, González M, Fernández MA, Perazzo JC, Savino EA, Varela A. Protection of ischaemic-reperfused rat heart by dimethylamiloride is associated with inhibition of mitochondrial permeability transition. Clin Exp Pharmacol Physiol. 2008 Feb;35(2):201-6. doi: 10.1111/j.1440-1681.2007.04800.x. Epub 2007 Oct 17. PMID: 17941897. 5: Doppler W, Hofmann J, Maly K, Grunicke H. Amiloride and 5-N,N-dimethylamiloride inhibit the carrier mediated uptake of choline in Ehrlich ascites tumor cells. Biochem Pharmacol. 1987 May 15;36(10):1645-9. doi: 10.1016/0006-2952(87)90049-9. PMID: 3593391. 6: Karwatowska-Prokopczuk E, Czarnowska E, Prokopczuk A. Combined therapy with dimethylthiourea, diltiazem and amiloride/dimethylamiloride in the ischemic/reperfused heart. Cardiovasc Res. 1995 Jul;30(1):70-8. PMID: 7553726. 7: Doppler W, Hofmann J, Maly K, Grunicke HH. Protection of Ehrlich ascites tumor cells against the antiproliferative effect of mechlorethamine (nitrogen mustard) by 5-N,N-dimethylamiloride. Cancer Res. 1988 May 1;48(9):2454-7. PMID: 3356009. 8: Davila-Calderon J, Li ML, Penumutchu SR, Haddad C, Malcolm L, King J, Hargrove AE, Brewer G, Tolbert BS. Enterovirus evolution reveals the mechanism of an RNA-targeted antiviral and determinants of viral replication. Sci Adv. 2024 Feb 16;10(7):eadg3060. doi: 10.1126/sciadv.adg3060. Epub 2024 Feb 16. PMID: 38363831; PMCID: PMC10871541. 9: Nylander O, Sjöblom M, Sedin J, Dahlgren D. Effects of α2-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum. PLoS One. 2022 Aug 25;17(8):e0273208. doi: 10.1371/journal.pone.0273208. PMID: 36006975; PMCID: PMC9409570. 10: Patwardhan NN, Ganser LR, Kapral GJ, Eubanks CS, Lee J, Sathyamoorthy B, Al- Hashimi HM, Hargrove AE. Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR. Medchemcomm. 2017 May 1;8(5):1022-1036. doi: 10.1039/C6MD00729E. Epub 2017 Mar 15. PMID: 28798862; PMCID: PMC5546750. 11: Hamilton JA. CSF-1 and cell cycle control in macrophages. Mol Reprod Dev. 1997 Jan;46(1):19-23. doi: 10.1002/(SICI)1098-2795(199701)46:1<19::AID- MRD4>3.0.CO;2-U. PMID: 8981359. 12: Lemasters JJ, Bond JM, Chacon E, Harper IS, Kaplan SH, Ohata H, Trollinger DR, Herman B, Cascio WE. The pH paradox in ischemia-reperfusion injury to cardiac myocytes. EXS. 1996;76:99-114. doi: 10.1007/978-3-0348-8988-9_7. PMID: 8805791. 13: Mitchell CH, Fleischhauer JC, Stamer WD, Peterson-Yantorno K, Civan MM. Human trabecular meshwork cell volume regulation. Am J Physiol Cell Physiol. 2002 Jul;283(1):C315-26. doi: 10.1152/ajpcell.00544.2001. PMID: 12055101. 14: Tsujimura T, Ueha R, Yoshihara M, Takei E, Nagoya K, Shiraishi N, Magara J, Inoue M. Involvement of the epithelial sodium channel in initiation of mechanically evoked swallows in anaesthetized rats. J Physiol. 2019 Jun;597(11):2949-2963. doi: 10.1113/JP277895. Epub 2019 May 8. PMID: 31032906. 15: Sepehrdad R, Chander PN, Singh G, Stier CT Jr. Sodium transport antagonism reduces thrombotic microangiopathy in stroke-prone spontaneously hypertensive rats. Am J Physiol Renal Physiol. 2004 Jun;286(6):F1185-92. doi: 10.1152/ajprenal.00355.2003. Epub 2004 Feb 24. PMID: 14982815. 16: Tanaka G, Nakase I, Fukuda Y, Masuda R, Oishi S, Shimura K, Kawaguchi Y, Takatani-Nakase T, Langel U, Gräslund A, Okawa K, Matsuoka M, Fujii N, Hatanaka Y, Futaki S. CXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV. Chem Biol. 2012 Nov 21;19(11):1437-46. doi: 10.1016/j.chembiol.2012.09.011. PMID: 23177198. 17: Lee GH, Chae HJ, Kim HR. Monoamine carboxylate transporters are involved in BI-1-associated cancer metastasis in HT1080 colon fibrosarcoma cells. Int J Oncol. 2011 Jul;39(1):209-16. doi: 10.3892/ijo.2011.1024. Epub 2011 Apr 29. PMID: 21537843. 18: Abdullah LH, Evans JR, Wang TT, Ford AA, Makhov AM, Nguyen K, Coakley RD, Griffith JD, Davis CW, Ballard ST, Kesimer M. Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways. JCI Insight. 2017 Mar 23;2(6):e89752. doi: 10.1172/jci.insight.89752. PMID: 28352653; PMCID: PMC5358479. 19: Carr MJ, Gover TD, Weinreich D, Undem BJ. Inhibition of mechanical activation of guinea-pig airway afferent neurons by amiloride analogues. Br J Pharmacol. 2001 Aug;133(8):1255-62. doi: 10.1038/sj.bjp.0704197. PMID: 11498511; PMCID: PMC1621149. 20: Mandal A, Shahidullah M, Delamere NA, Terán MA. Elevated hydrostatic pressure activates sodium/hydrogen exchanger-1 in rat optic nerve head astrocytes. Am J Physiol Cell Physiol. 2009 Jul;297(1):C111-20. doi: 10.1152/ajpcell.00539.2008. Epub 2009 May 6. PMID: 19419999; PMCID: PMC2711650.