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MedKoo Cat#: 125950 | Name: Antofloxacin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Antofloxacin is a fluoroquinolone antimicrobial used to treat acute exacerbation of chronic bronchitis (AECB), acute pyelonephritis(AP), acute cystitis and multiple folliculitis.

Chemical Structure

Antofloxacin
Antofloxacin
CAS#119354-43-7 (free base)

Theoretical Analysis

MedKoo Cat#: 125950

Name: Antofloxacin

CAS#: 119354-43-7 (free base)

Chemical Formula: C18H21FN4O4

Exact Mass: 376.1547

Molecular Weight: 376.39

Elemental Analysis: C, 57.44; H, 5.62; F, 5.05; N, 14.89; O, 17.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
119354-43-7 (free base) 873888-67-6 (HCl)
Synonym
Antofloxacin; (S)-Antofloxacin; 119354-43-7
IUPAC/Chemical Name
(S)-8-amino-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
InChi Key
MHFCVNDHFSOKMK-VIFPVBQESA-N
InChi Code
InChI=1S/C18H21FN4O4/c1-9-8-27-17-14-11(16(24)10(18(25)26)7-23(9)14)13(20)12(19)15(17)22-5-3-21(2)4-6-22/h7,9H,3-6,8,20H2,1-2H3,(H,25,26)/t9-/m0/s1
SMILES Code
C[C@H]1COC2=C3N1C=C(C(O)=O)C(=O)C3=C(N)C(F)=C2N4CCN(C)CC4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu L, Pan X, Liu HY, Liu XD, Yang HW, Xie L, Cheng JL, Fan HW, Xiao DW. Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans. Acta Pharmacol Sin. 2011 Oct;32(10):1285-93. doi: 10.1038/aps.2011.78. PubMed PMID: 21892200; PubMed Central PMCID: PMC4010077. 2: Wang J, Xiao Y, Lu Y, Kang Z, Zhang M, Liu Y, Liang J, Zhang M, Li T. Pharmacokinetics of antofloxacin hydrochloride in healthy male subjects after multiple intravenous dose administration. Xenobiotica. 2011 Jul;41(7):561-6. doi: 10.3109/00498254.2011.565820. PubMed PMID: 21446836. 3: Lü Y, Kang ZS, Zhu Y, Zhang M, Liu Y, Zhang M, Li TY, Xiao YH. Pharmacokinetic study of single and multiple oral dose administration of antofloxacin hydrochloride in healthy male volunteers. Chin Med J (Engl). 2011 Jan;124(2):242-5. PubMed PMID: 21362374. 4: Zhao J, Liu Y, Jiang X, Guo P, Xu Y, Zhang P, Ji T, Lin Z, Wang W. Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study. J Photochem Photobiol B. 2016 Feb;155:122-9. doi: 10.1016/j.jphotobiol.2015.12.004. PubMed PMID: 26746788. 5: Li YF, Wang K, Yin F, He YC, Huang JH, Zheng QS. Dose findings of antofloxacin hydrochloride for treating bacterial infections in an early clinical trial using PK-PD parameters in healthy volunteers. Acta Pharmacol Sin. 2012 Nov;33(11):1424-30. doi: 10.1038/aps.2012.68. PubMed PMID: 22864303; PubMed Central PMCID: PMC4011355. 6: Xiao YH, Cui H, Xue F, Huang WX, Xiu QY, Li DT, Chen P, Jia ZP, Wen AD, Yang GP, Mao GG. [A multi-center, randomized, controlled, double blind and double dummy clinical trial of antofloxacin hydrochloride tablet versus levofloxacin tablet for the treatment of acute bacterial infections]. Zhonghua Nei Ke Za Zhi. 2011 Mar;50(3):225-9. Chinese. PubMed PMID: 21600087. 7: Wang J, Xiao Y, Lu Y, Kang Z, Zhang M, Liu Y, Liang J, Zhang M, Li T. Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers. Xenobiotica. 2010 May;40(5):344-9. doi: 10.3109/00498251003649798. PubMed PMID: 20230254. 8: Zhu Q, Liao J, Xie L, Wang GJ, Liu XD. Mechanism-based inhibition of CYP1A2 by antofloxacin, an 8-NH2 derivative of levofloxacin in rats. Xenobiotica. 2009 Apr;39(4):293-301. doi: 10.1080/00498250802709428. PubMed PMID: 19350452. 9: Wang J, Xiao Y, Huang W, Xu N, Bai C, Xiu Q, Mei C, Zheng Q. A phase II study of antofloxacin hydrochloride, a novel fluoroquinolone, for the treatment of acute bacterial infections. Chemotherapy. 2010;56(5):378-85. doi: 10.1159/000317581. PubMed PMID: 20938175. 10: Xu X, Liu HY, Liu L, Xie L, Liu XD. The influence of a newly developed quinolone: antofloxacin, on CYP activity in rats. Eur J Drug Metab Pharmacokinet. 2008 Jan-Mar;33(1):1-7. PubMed PMID: 18543578. 11: Pang XY, Liu L, Zhang DM, Wang GJ, Xie L, Liu XD. The pharmacokinetics of antofloxacin in renally impaired rats. J Pharm Pharmacol. 2008 May;60(5):667-70. doi: 10.1211/jpp.60.5.0014. PubMed PMID: 18416945. 12: Xiao Y, Lu Y, Kang Z, Zhang M, Liu Y, Zhang M, Li T. Pharmacokinetics of antofloxacin hydrochloride, a new fluoroquinolone antibiotic, after single oral dose administration in Chinese healthy male volunteers. Biopharm Drug Dispos. 2008 Apr;29(3):167-72. doi: 10.1002/bdd.600. PubMed PMID: 18240275. 13: Liang Y, Liu L, Lu S, Xie L, Kang A, Xie T, Xie Y, Sheng L, Liu X, Wang GJ. Application of a hybrid ion trap/time-of-flight mass spectrometer in metabolite characterization studies: structural identification of the metabolism profile of antofloxacin in rats rapidly using MSn information and accurate mass measurements. J Pharm Biomed Anal. 2009 Dec 5;50(5):1022-5. doi: 10.1016/j.jpba.2009.05.008. PubMed PMID: 19632077. 14: Xiao Y, Lu Y, Kang Z, Hou F, Wang S, Li T, Liu Y, Xia Y. Tolerability and pharmacokinetics of antofloxacin hydrochloride after multiple oral dose administration in healthy Chinese male volunteers. Int J Clin Pharmacol Ther. 2008 Apr;46(4):172-9. PubMed PMID: 18397690. 15: Xiao XM, Xiao YH. Pharmacokinetics/pharmacodynamics of antofloxacin hydrochloride in a neutropenic murine thigh model of Staphylococcus aureus infection. Acta Pharmacol Sin. 2008 Oct;29(10):1253-60. doi: 10.1111/j.1745-7254.2008.00872.x. PubMed PMID: 18817632.