Berlafenone | CAS#18965-97-4 | GK 23 G | sodium channel antagonist | class Ic antiarrhythmic agent

MedKoo Cat#: 125946 | Name: Berlafenone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Berlafenone (previously known as GK 23 G), a sodium channel antagonist was studied as a class Ic antiarrhythmic agent.

Chemical Structure

Berlafenone

CAS#18965-97-4 (free base)

Theoretical Analysis

MedKoo Cat#: 125946

Name: Berlafenone

CAS#: 18965-97-4 (free base)

Chemical Formula: C19H25NO2

Exact Mass: 299.1885

Molecular Weight: 299.41

Elemental Analysis: C, 76.22; H, 8.42; N, 4.68; O, 10.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

18965-97-4 (free base) 18965-98-5 (HCl)

Synonym

Berlafenone; Bipranol; 18965-97-4; GK-23-G; GK 23 G;

IUPAC/Chemical Name

1-([1,1'-biphenyl]-2-yloxy)-3-(tert-butylamino)propan-2-ol

InChi Key

DBHPVKNFKBKJCE-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H25NO2/c1-19(2,3)20-13-16(21)14-22-18-12-8-7-11-17(18)15-9-5-4-6-10-15/h4-12,16,20-21H,13-14H2,1-3H3

SMILES Code

CC(C)(C)NCC(COC1=CC=CC=C1C2=CC=CC=C2)O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 299.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Chiladakis I, Hindricks G, Haverkamp W, Vogt J, Gülker H. Electrophysiologic, haemodynamic and antiarrhythmic effects of the new class Ic agent 1-(2'-biphenyloxy)-2-tert.-butylamino-propanol-2-hydrochloride. Arzneimittelforschung. 1989 Sep;39(9):1130-2. PMID: 2590263. 2. Rose H, Ionescu I, Pöpping S, Fischer Y, Kammermeier H. Negative inotropic effects of the new class I antiarrhythmic agents berlafenone and alprafenone on electrically stimulated isolated cardiomyocytes. Arzneimittelforschung. 1992 Mar;42(3):289-91. PMID: 1497686.