Saredutant, aslo known as SR-48968, is a NK2 receptor antagonist for the treatment of major depressive disorder. Saredutant has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant, ameliorates stress-induced conditions without impairing cognition. SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex. SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
MedKoo Cat#: 125875
Name: Saredutant succinate
CAS#: 176381-98-9 (succinate)
Chemical Formula: C35H41Cl2N3O6
Exact Mass: 669.2372
Molecular Weight: 670.63
Elemental Analysis: C, 62.69; H, 6.16; Cl, 10.57; N, 6.27; O, 14.31
The following data is based on the product molecular weight 670.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
