Tricyclic cytosine tC | fluorescent cytosine analog | imaging RNA | CAS#1174063-74-1

MedKoo Cat#: 125772 | Name: Tricyclic cytosine tC

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tricyclic cytosine tC is a fluorescent cytosine analog for imaging RNA in living cells.

Chemical Structure

Tricyclic cytosine tC

CAS#1174063-74-1

Theoretical Analysis

MedKoo Cat#: 125772

Name: Tricyclic cytosine tC

CAS#: 1174063-74-1

Chemical Formula: C15H15N3O5S

Exact Mass: 349.0700

Molecular Weight: 349.36

Elemental Analysis: C, 51.57; H, 4.33; N, 12.03; O, 22.90; S, 9.18

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 500.00	2 Weeks

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Related CAS #

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Synonym

Tricyclic cytosine tC; Tricyclic-cytosine tC; Tricyclic cytosine-tC

IUPAC/Chemical Name

3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-benzo[b]pyrimido[4,5-e][1,4]thiazin-2(10H)-one

InChi Key

SRXXFIYNNTZZBB-LHNIVKCTSA-N

InChi Code

InChI=1S/C15H15N3O5S/c19-6-8-11(20)12(21)14(23-8)18-5-10-13(17-15(18)22)16-7-3-1-2-4-9(7)24-10/h1-5,8,11-12,14,19-21H,6H2,(H,16,17,22)/t8-,11-,12-,14-/m1/s1

SMILES Code

O[C@H]1[C@H](N2C(N=C3C(SC4=CC=CC=C4N3)=C2)=O)O[C@@H]([C@H]1O)CO

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 349.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bielecka P, Juskowiak B. Fluorescent Sensor for PH Monitoring Based on an i-Motif---Switching Aptamer Containing a Tricyclic Cytosine Analogue (tC). Molecules. 2015 Oct 9;20(10):18511-25. doi: 10.3390/molecules201018511. PMID: 26473815; PMCID: PMC6332284. 2: Preus S, Kilså K, Wilhelmsson LM, Albinsson B. Photophysical and structural properties of the fluorescent nucleobase analogues of the tricyclic cytosine (tC) family. Phys Chem Chem Phys. 2010 Aug 21;12(31):8881-92. doi: 10.1039/c000625d. Epub 2010 Jun 8. PMID: 20532361. 3: Sandin P, Lincoln P, Brown T, Wilhelmsson LM. Synthesis and oligonucleotide incorporation of fluorescent cytosine analogue tC: a promising nucleic acid probe. Nat Protoc. 2007;2(3):615-23. doi: 10.1038/nprot.2007.80. PMID: 17406622.