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MedKoo Cat#: 576875 | Name: Maprotiline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Maprotiline is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.

Chemical Structure

Maprotiline
Maprotiline
CAS#10262-69-8 (free base)

Theoretical Analysis

MedKoo Cat#: 576875

Name: Maprotiline

CAS#: 10262-69-8 (free base)

Chemical Formula: C20H23N

Exact Mass: 277.1830

Molecular Weight: 277.41

Elemental Analysis: C, 86.59; H, 8.36; N, 5.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
10347-81-6 (HCl) 10262-69-8 (free base) 58902-67-3 (mesylate) 1329496-63-0 (d3 HCl)
Synonym
Maprotiline
IUPAC/Chemical Name
9,10-Ethanoanthracene-9(10H)-propylamine, N-methyl-
InChi Key
QSLMDECMDJKHMQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3
SMILES Code
CNCCCC12CCC(c3ccccc13)c4ccccc24
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 277.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schwartz L, Swaminathan S. Maprotiline hydrochloride and convulsions: a case report. Am J Psychiatry. 1982 Feb;139(2):244-5. PubMed PMID: 6798885. 2: Wells BG, Gelenberg AJ. Chemistry, pharmacology, pharmacokinetics, adverse effects, and efficacy of the antidepressant maprotiline hydrochloride. Pharmacotherapy. 1981 Sep-Oct;1(2):121-39. PubMed PMID: 6765485. 3: Atri PB, Julius DA. Maprotiline hydrochloride associated with a clinical state of catatonic stupor and epileptic encephalogram. J Clin Psychopharmacol. 1984 Aug;4(4):207-9. PubMed PMID: 6470193. 4: Multicenter evaluation of maprotiline hydrochloride for treatment of depression. Clin Ther. 1984;6(2):155-62. PubMed PMID: 6367987. 5: Treatment of depression with maprotiline hydrochloride: multicenter evaluation of efficacy and tolerability. Clin Ther. 1983;5(4):377-84. PubMed PMID: 6347381.

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