Synonym
BDW568; BDW 568; BDW-568
IUPAC/Chemical Name
methyl 2-((8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl)thio)acetate
InChi Key
RNNRGNUAQCUYEG-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H12N4O2S2/c1-6-7(2)20-11-9(6)10-14-15-12(16(10)5-13-11)19-4-8(17)18-3/h5H,4H2,1-3H3
SMILES Code
O=C(OC)CSC1=NN=C2N1C=NC3=C2C(C)=C(C)S3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
308.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tang Z, Zhao J, Li Y, Tomer S, Selvaraju M, Tien N, Sun D, Johnson DK, Zhen
A, Li P, Wang J. Structural and Biological Evaluations of a Non-Nucleoside STING
Agonist Specific for Human STINGA230 Variants. bioRxiv [Preprint].
2023 Jul 10:2023.07.02.547363. doi: 10.1101/2023.07.02.547363. PMID: 37425806;
PMCID: PMC10327114.
2: Zhao J, Tang Z, Selvaraju M, Johnson KA, Douglas JT, Gao PF, Petrassi HM,
Wang MZ, Wang J. Cellular Target Deconvolution of Small Molecules Using a
Selection-Based Genetic Screening Platform. ACS Cent Sci. 2022 Oct
26;8(10):1424-1434. doi: 10.1021/acscentsci.2c00609. Epub 2022 Sep 22. PMID:
36313155; PMCID: PMC9615120.
