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MedKoo Cat#: 561231 | Name: KM05382

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KM05382 is a CDK9 inhibitor. KM05382 also inhibits the transcription of GAPDH.

Chemical Structure

KM05382
KM05382
CAS#882291-64-7

Theoretical Analysis

MedKoo Cat#: 561231

Name: KM05382

CAS#: 882291-64-7

Chemical Formula: C20H19ClN2O3S2

Exact Mass: 434.0526

Molecular Weight: 434.95

Elemental Analysis: C, 55.23; H, 4.40; Cl, 8.15; N, 6.44; O, 11.03; S, 14.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KM05382; KM 05382; KM-05382
IUPAC/Chemical Name
2-[(3-Cyano-5,5-dimethyl-7-oxo-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)thio]ethyl N-(3-chlorophenyl)carbamate
InChi Key
PZWYPKZFOBEQEI-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H19ClN2O3S2/c1-20(2)9-14-16(11-22)28-18(17(14)15(24)10-20)27-7-6-26-19(25)23-13-5-3-4-12(21)8-13/h3-5,8H,6-7,9-10H2,1-2H3,(H,23,25)
SMILES Code
O=C(OCCSC1=C2C(CC(C)(C)CC2=O)=C(C#N)S1)NC3=CC=CC(Cl)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 434.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Giono LE, Kornblihtt AR. A bumpy road for RNA polymerase II. Nat Struct Mol Biol. 2015 May;22(5):353-5. doi: 10.1038/nsmb.3020. PubMed PMID: 25945884. 2: Laitem C, Zaborowska J, Isa NF, Kufs J, Dienstbier M, Murphy S. CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes. Nature structural & molecular biology. 2015;22(5):396-403. doi:10.1038/nsmb.3000.

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