CCX662 is a highly potent and selective small molecule inhibitor of CXCR7. CCX662 inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM in buffer, and displays minimal serum shift with an IC50 of 18 nM in 100% human serum. CCX662 inhibits the CXCR4-directed trans-endothelial migration of CXCR4+/CXCR7+ NC37 cells towards CXCL12 (SDF1) with an IC50 of 106 nM. CCX662 also potently inhibits binding of 125I-CXCL12 to rat CXCR7 in the presence of 100% rat serum with an IC50 of 14 nM. In vivo inhibition of CXCR7 with CCX662, in concert with radiotherapy, results in a significant extension of survival time in the ENU-induced rat model of GBM.
MedKoo Cat#: 125739
Name: CCX662
CAS#: 1226686-54-9
Chemical Formula: C28H37N5O4S
Exact Mass: 539.2600
Molecular Weight: 539.70
Elemental Analysis: C, 62.31; H, 6.91; N, 12.98; O, 11.86; S, 5.94
The following data is based on the product molecular weight 539.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
