JN122 is a highly potent spiroindoline-containing MDM2 inhibitor. JN122 exhibited moderate activities against MDM4/p53 interactions. In a panel of cancer cell lines harboring wild type p53, JN122 efficiently promoted activation of p53 and its target genes, inhibited cell cycle progression, and induced cell apoptosis. Interestingly, JN122 also promoted degradation of MDM4. More importantly, JN122 exhibited good PK properties and exerted robust antitumor efficacies in a systemic mouse xenograft model of MOLM-13.
MedKoo Cat#: 125733
Name: JN122
CAS#: N/A
Chemical Formula: C33H37Cl2N3O4
Exact Mass: 609.2200
Molecular Weight: 610.58
Elemental Analysis: C, 64.92; H, 6.11; Cl, 11.61; N, 6.88; O, 10.48
The following data is based on the product molecular weight 610.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
