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MedKoo Cat#: 125719 | Name: HD-TAC7
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

HD-TAC7 is a selective HDAC3 degrader.

Chemical Structure

HD-TAC7
HD-TAC7
CAS#2978763-95-8

Theoretical Analysis

MedKoo Cat#: 125719

Name: HD-TAC7

CAS#: 2978763-95-8

Chemical Formula: C33H32FN7O7

Exact Mass: 657.2300

Molecular Weight: 657.66

Elemental Analysis: C, 60.27; H, 4.90; F, 2.89; N, 14.91; O, 17.03

Price and Availability

Size Price Availability Quantity
5mg USD 850.00 2 Weeks
10mg USD 1,450.00 2 Weeks
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Related CAS #
No Data
Synonym
HD-TAC7; HD TAC7; HDTAC7
IUPAC/Chemical Name
N-(2-amino-4-fluorophenyl)-4-(5-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)pentanamido)benzamide
InChi Key
AMBNMDIPGZXRRW-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H32FN7O7/c34-19-9-12-23(22(35)16-19)39-30(45)18-7-10-20(11-8-18)38-26(42)6-1-2-15-36-28(44)17-37-24-5-3-4-21-29(24)33(48)41(32(21)47)25-13-14-27(43)40-31(25)46/h3-5,7-12,16,25,37H,1-2,6,13-15,17,35H2,(H,36,44)(H,38,42)(H,39,45)(H,40,43,46)
SMILES Code
O=C(NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1)CCCCNC(CNC3=CC=CC(C(N4C5CCC(NC5=O)=O)=O)=C3C4=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 657.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zahid S, Ali Y, Rashid S. Structural-based design of HD-TAC7 PROteolysis TArgeting chimeras (PROTACs) candidate transformations to abrogate SARS-CoV-2 infection. J Biomol Struct Dyn. 2023 Feb 25:1-16. doi: 10.1080/07391102.2023.2183037. Epub ahead of print. PMID: 36841549. 2: Cao F, de Weerd S, Chen D, Zwinderman MRH, van der Wouden PE, Dekker FJ. Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC). Eur J Med Chem. 2020 Dec 15;208:112800. doi: 10.1016/j.ejmech.2020.112800. Epub 2020 Sep 6. PMID: 32971411.