GB1490 is a Galectin‑1 Inhibitor. The X-ray structure of GB1490 bound to galectin-1 reveals the compound bound in a single conformation in the carbohydrate binding site. GB1490 was shown to reverse galectin-1-induced apoptosis of Jurkat cells at low μM concentrations. No cell cytotoxicity was observed for GB1490 up to 90 μM in the A549 cells. In pharmacokinetic studies in mice, GB1490 showed high oral bioavailability (F% > 99%).
MedKoo Cat#: 125716
Name: GB1490
CAS#: N/A
Chemical Formula: C17H15Cl2FN4O4S2
Exact Mass: 491.9900
Molecular Weight: 493.35
Elemental Analysis: C, 41.39; H, 3.06; Cl, 14.37; F, 3.85; N, 11.36; O, 12.97; S, 13.00
The following data is based on the product molecular weight 493.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
