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MedKoo Cat#: 597020 | Name: Felinine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Felinine is a sulfur-containing amino acid; a major component in the urine of domestic cat.

Chemical Structure

Felinine
Felinine
CAS#471-09-0

Theoretical Analysis

MedKoo Cat#: 597020

Name: Felinine

CAS#: 471-09-0

Chemical Formula: C8H17NO3S

Exact Mass: 207.0929

Molecular Weight: 207.28

Elemental Analysis: C, 46.35; H, 8.27; N, 6.76; O, 23.15; S, 15.47

Price and Availability

Felinine purity > 98%, is available via customer synthesis. Lead time is 1-2 months. We accept orders now.
Related CAS #
No Data
Synonym
Felinine; L-Felinine; (-)-felinine;
IUPAC/Chemical Name
S-(4-hydroxy-2-methylbutan-2-yl)-L-cysteine
InChi Key
IFERABFGYYJODC-LURJTMIESA-N
InChi Code
InChI=1S/C8H17NO3S/c1-8(2,3-4-10)13-5-6(9)7(11)12/h6,10H,3-5,9H2,1-2H3,(H,11,12)/t6-/m0/s1
SMILES Code
N[C@@H](CSC(C)(C)CCO)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 207.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Miyazaki M, Miyazaki T, Nishimura T, Hojo W, Yamashita T. The Chemical Basis of Species, Sex, and Individual Recognition Using Feces in the Domestic Cat. J Chem Ecol. 2018 Apr;44(4):364-373. doi: 10.1007/s10886-018-0951-3. Epub 2018 Apr 10. PubMed PMID: 29637491. 2: Futsuta A, Hojo W, Miyazaki T, Yamashita T, Miyazaki M. LC-MS/MS quantification of felinine metabolites in tissues, fluids, and excretions from the domestic cat (Felis catus). J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:94-99. doi: 10.1016/j.jchromb.2017.11.006. Epub 2017 Nov 6. PubMed PMID: 29145026. 3: Allaway D, Gilham MS, Colyer A, Jönsson TJ, Swanson KS, Morris PJ. Metabolic Profiling Reveals Effects of Age, Sexual Development and Neutering in Plasma of Young Male Cats. PLoS One. 2016 Dec 12;11(12):e0168144. doi: 10.1371/journal.pone.0168144. eCollection 2016. PubMed PMID: 27942045; PubMed Central PMCID: PMC5152928. 4: Cibaka ML, Gros J, Nizet S, Collin S. Quantitation of selected terpenoids and mercaptans in the dual-purpose hop varieties Amarillo, Citra, Hallertau Blanc, Mosaic, and Sorachi Ace. J Agric Food Chem. 2015 Mar 25;63(11):3022-30. doi: 10.1021/jf5058556. Epub 2015 Mar 17. PubMed PMID: 25780945. 5: Barry KA, Hernot DC, Van Loo J, Fahey GC Jr, de Godoy MR. Fructan supplementation of senior cats affects stool metabolite concentrations and fecal microbiota concentrations, but not nitrogen partitioning in excreta. J Anim Sci. 2014 Nov;92(11):4964-71. doi: 10.2527/jas.2013-7510. PubMed PMID: 25349345. 6: Voznessenskaya VV. Influence of Cat Odor on Reproductive Behavior and Physiology in the House Mouse: (Mus Musculus). In: Mucignat-Caretta C, editor. Neurobiology of Chemical Communication. Boca Raton (FL): CRC Press/Taylor & Francis; 2014. Chapter 14. PubMed PMID: 24830030. 7: Voznessenskaya VV, Malanina TV. Effect of chemical signals from a predator (Felis catus) on the reproduction of Mus musculus. Dokl Biol Sci. 2013 Nov;453:362-4. doi: 10.1134/S0012496613060057. Epub 2014 Jan 3. PubMed PMID: 24385171. 8: Hagen-Plantinga EA, Bosch G, Hendriks WH. Felinine excretion in domestic cat breeds: a preliminary investigation. J Anim Physiol Anim Nutr (Berl). 2014 Jun;98(3):491-6. doi: 10.1111/jpn.12097. Epub 2013 Jul 2. PubMed PMID: 23819478. 9: Flegr J, Lenochová P, Hodný Z, Vondrová M. Fatal attraction phenomenon in humans: cat odour attractiveness increased for toxoplasma-infected men while decreased for infected women. PLoS Negl Trop Dis. 2011 Nov;5(11):e1389. doi: 10.1371/journal.pntd.0001389. Epub 2011 Nov 8. PubMed PMID: 22087345; PubMed Central PMCID: PMC3210761. 10: Li G, Janecka JE, Murphy WJ. Accelerated evolution of CES7, a gene encoding a novel major urinary protein in the cat family. Mol Biol Evol. 2011 Feb;28(2):911-20. doi: 10.1093/molbev/msq281. Epub 2010 Oct 21. PubMed PMID: 20966115. 11: Rezzi S, Vera FA, Martin FP, Wang S, Lawler D, Kochhar S. Automated SPE-RP-HPLC fractionation of biofluids combined to off-line NMR spectroscopy for biomarker identification in metabonomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 15;871(2):271-8. doi: 10.1016/j.jchromb.2008.04.001. Epub 2008 Apr 8. PubMed PMID: 18439883. 12: Hendriks WH, Rutherfurd-Markwick KJ, Weidgraaf K, Hugh Morton R, Rogers QR. Urinary felinine excretion in intact male cats is increased by dietary cystine. Br J Nutr. 2008 Oct;100(4):801-9. doi: 10.1017/S0007114508945165. Epub 2008 Mar 17. PubMed PMID: 18341755. 13: Hendriks WH, Rutherfurd-Markwick KJ, Weidgraaf K, Ugarte C, Rogers QR. Testosterone increases urinary free felinine, N-acetylfelinine and methylbutanolglutathione excretion in cats (Felis catus). J Anim Physiol Anim Nutr (Berl). 2008 Feb;92(1):53-62. doi: 10.1111/j.1439-0396.2007.00710.x. PubMed PMID: 18184380. 14: Matsumoto K, Funaba M. Factors affecting struvite (MgNH4PO4.6H2O) crystallization in feline urine. Biochim Biophys Acta. 2008 Feb;1780(2):233-9. Epub 2007 Sep 29. PubMed PMID: 17976920. 15: Dieterle F, Schlotterbeck G, Binder M, Ross A, Suter L, Senn H. Application of metabonomics in a comparative profiling study reveals N-acetylfelinine excretion as a biomarker for inhibition of the farnesyl pathway by bisphosphonates. Chem Res Toxicol. 2007 Sep;20(9):1291-9. Epub 2007 Aug 4. PubMed PMID: 17676813. 16: Miyazaki M, Yamashita T, Suzuki Y, Saito Y, Soeta S, Taira H, Suzuki A. A major urinary protein of the domestic cat regulates the production of felinine, a putative pheromone precursor. Chem Biol. 2006 Oct;13(10):1071-9. PubMed PMID: 17052611. 17: Rutherfurd SM, Kitson TM, Woolhouse AD, McGrath MC, Hendriks WH. Felinine stability in the presence of selected urine compounds. Amino Acids. 2007 Feb;32(2):235-42. Epub 2006 Jul 31. PubMed PMID: 16868647. 18: Hendriks WH, Harding DR, Rutherfurd-Markwick KJ. Isolation and characterisation of renal metabolites of gamma-glutamylfelinylglycine in the urine of the domestic cat (Felis catus). Comp Biochem Physiol B Biochem Mol Biol. 2004 Oct;139(2):245-51. PubMed PMID: 15465671. 19: Rutherfurd SM, Zhang F, Harding DR, Woolhouse AD, Hendriks WH. Use of capillary (zone) electrophoresis for determining felinine and it's application to investigate the stability of felinine. Amino Acids. 2004 Aug;27(1):49-55. Epub 2004 Jun 4. PubMed PMID: 15309571. 20: Hendriks WH, Vather R, Rutherfurd SM, Weidgraaf K, Rutherfurd-Markwick KJ. Urinary isovalthine excretion in adult cats is not gender dependent or increased by oral leucine supplementation. J Nutr. 2004 Aug;134(8 Suppl):2114S-2116S. doi: 10.1093/jn/134.8.2114S. PubMed PMID: 15284413.