GC-78 is a Noncovalent Severe Acute Respiratory Syndrome Corona virus 2 Main Protease Inhibitor with Improved Antiviral Activity. GC-78 demonstrated high enzyme−inhibitory potency (IC50 = 0.19μM) and exhibited excellent antiviral activity (EC50 = 0.40μM),reaching the same level as Nirmatrelvir (EC50= 0.38μM). Additionally,GC-78 displayed potent antiviral activitie sagainst various SARS-CoV-2 variants as well as HCoV-OC 43 and HCoV-229E, indicating its potential broad-spectrum anticoronaviral activity. Notably,the pharmacokinetic propertiesof GC-78 were some what enhanced compared to those of the lead compound. Furthermore, the cocrystaland molecular docking elucidated the mechanism of action.
MedKoo Cat#: 125630
Name: GC-78 HCl
CAS#: 3022242-53-8
Chemical Formula: C25H25Cl3N4O4
Exact Mass: 550.0900
Molecular Weight: 551.85
Elemental Analysis: C, 54.41; H, 4.57; Cl, 19.27; N, 10.15; O, 11.60
The following data is based on the product molecular weight 551.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
