Synonym
Prodipine hydrochloride; 31314-39-3; ANTHEN; 89CCP8Z2PS; Prodipine hydrochloride [MI]
IUPAC/Chemical Name
1-isopropyl-4,4-diphenylpiperidine hydrochloride
InChi Key
ZFCBOUXJVGNRIF-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H25N.ClH/c1-17(2)21-15-13-20(14-16-21,18-9-5-3-6-10-18)19-11-7-4-8-12-19;/h3-12,17H,13-16H2,1-2H3;1H
SMILES Code
Cl.CC(C)N1CCC(CC1)(C2=CC=CC=C2)C3=CC=CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
315.89
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: De Meester I, Belyaev A, Lambeir AM, De Meyer GR, Van Osselaer N, Haemers A,
Scharpé S. In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro-
diphenyl-phosphonate (Prodipine). Biochem Pharmacol. 1997 Jul 1;54(1):173-9.
doi: 10.1016/s0006-2952(97)00149-4. PMID: 9296364.
2: Eltze M. The effects of prodipine and budipine on 14C-5-hydroxytryptamine
uptake and release by human blood platelets. Arzneimittelforschung.
1980;30(7):1129-34. PMID: 7191294.
3: Gründig E, Gerstenbrand F. Vergleichende Untersuchungen über die Wirkung von
L-Dopa Prodipin und Amantadin auf den Aminosäurespiegel von Serum und Liquor
beim Parkinson-Syndrom [Comparison between the effects of L-dopa, prodipine and
amantadine on the serum and CSF amino acid levels in Parkinson's disease
(author's transl)]. Wien Klin Wochenschr. 1980 Dec 19;92(24):868-71. German.
PMID: 7222702.
4: Korom S, De Meester I, Stadlbauer TH, Chandraker A, Schaub M, Sayegh MH,
Belyaev A, Haemers A, Scharpé S, Kupiec-Weglinski JW. Inhibition of
CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft
survival in rat recipients. Transplantation. 1997 May 27;63(10):1495-500. doi:
10.1097/00007890-199705270-00021. PMID: 9175816.
5: de Groot MJ, Bijloo GJ, van Acker FA, Fonseca Guerra C, Snijders JG,
Vermeulen NP. Extension of a predictive substrate model for human cytochrome
P4502D6. Xenobiotica. 1997 Apr;27(4):357-68. doi: 10.1080/004982597240514. PMID:
9149375.
6: Oppel F, Schulze G. CSF-changes of HVA and 5-HIAA during intermittent and
continuous Parkinson therapy with particular regard to prodipin application.
Pharmakopsychiatr Neuropsychopharmakol. 1978 Mar;11(2):76-80. doi:
10.1055/s-0028-1094565. PMID: 347467.
