MedKoo Cat#: 125481 | Name: GSK-424887

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-424887 is a dual antagonist of the human neurokinin receptor 1 and inhibitor of the serotonin transporter.

Chemical Structure

GSK-424887
GSK-424887
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125481

Name: GSK-424887

CAS#: N/A

Chemical Formula: C27H30ClFN2O

Exact Mass: 452.2000

Molecular Weight: 453.00

Elemental Analysis: C, 71.59; H, 6.68; Cl, 7.83; F, 4.19; N, 6.18; O, 3.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GSK-424887; GSK424887; IYI99KCF2T; CHEMBL4297387; DB12219; GSK 424887
IUPAC/Chemical Name
(S)-N-(1-(3-chloronaphthalen-1-yl)ethyl)-2-(4-(4-fluorophenyl)-1-methylpiperidin-4-yl)-N-methylacetamide
InChi Key
DRXBWLBZWAJIEF-IBGZPJMESA-N
InChi Code
InChI=1S/C27H30ClFN2O/c1-19(25-17-22(28)16-20-6-4-5-7-24(20)25)31(3)26(32)18-27(12-14-30(2)15-13-27)21-8-10-23(29)11-9-21/h4-11,16-17,19H,12-15,18H2,1-3H3/t19-/m0/s1
SMILES Code
C[C@H](N(C)C(=O)CC1(CCN(C)CC1)C2=CC=C(F)C=C2)C3=C4C=CC=CC4=CC(Cl)=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 453.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Harmer CJ, Dawson GR, Dourish CT, Favaron E, Parsons E, Fiore M, Zucchetto M, Bifone A, Poggesi I, Fernandes S, Alexander RC, Goodwin GM. Combined NK₁ antagonism and serotonin reuptake inhibition: effects on emotional processing in humans. J Psychopharmacol. 2013 May;27(5):435-43. doi: 10.1177/0269881112472558. Epub 2013 Feb 12. PMID: 23407644.