Synonym
NS 1608; NS1608; NS-1608
IUPAC/Chemical Name
N-(3-(Trifluoromethyl)phenyl)-N'-(2-hydroxy-5-chlorophenyl)urea
InChi Key
KRHJDJMOIKRPNN-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H10ClF3N2O2/c15-9-4-5-12(21)11(7-9)20-13(22)19-10-3-1-2-8(6-10)14(16,17)18/h1-7,21H,(H2,19,20,22)
SMILES Code
O=C(NC1=CC(Cl)=CC=C1O)NC2=CC=CC(C(F)(F)F)=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
330.69
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Strøbaek D, Christophersen P, Holm NR, Moldt P, Ahring PK, Johansen TE, Olesen SP. Modulation of the Ca(2+)-dependent K+ channel, hslo, by the substituted diphenylurea NS 1608, paxilline and internal Ca2+. Neuropharmacology. 1996;35(7):903-14. PubMed PMID: 8938721.
2: Mora TC, Suarez-Kurtz G. Effects of NS1608, a BK(Ca) channel agonist, on the contractility of guinea-pig urinary bladder in vitro. Br J Pharmacol. 2005 Mar;144(5):636-41. PubMed PMID: 15678097; PubMed Central PMCID: PMC1576041.
3: Hu S, Kim HS, Fink CA. Differential effects of the BKCa channel openers NS004 and NS1608 in porcine coronary arterial cells. Eur J Pharmacol. 1995 Dec 27;294(1):357-60. PubMed PMID: 8788454.
4: Ahring PK, Strøbaek D, Christophersen P, Olesen SP, Johansen TE. Stable expression of the human large-conductance Ca2+-activated K+ channel alpha- and beta-subunits in HEK293 cells. FEBS Lett. 1997 Sep 22;415(1):67-70. PubMed PMID: 9326371.
5: Hu S, Kim HS. On the mechanism of the differential effects of NS004 and NS1608 in smooth muscle cells from guinea pig bladder. Eur J Pharmacol. 1996 Dec 30;318(2-3):461-8. PubMed PMID: 9016939.
6: Siemer C, Bushfield M, Newgreen D, Grissmer S. Effects of NS1608 on MaxiK channels in smooth muscle cells from urinary bladder. J Membr Biol. 2000 Jan 1;173(1):57-66. PubMed PMID: 10612692. a
