MedKoo Cat#: 125450 | Name: Phencarbamide HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phencarbamide is an anti-spasmodic and anticholinergic drug used during parturition. It has a specific antispasmodic action on the smooth muscle, both directly like papaverine and through the autonomic nervous system (atropine effect). It has also an analgesic effect of its own. Side-effects generally associated with the atropine group of drugs.

Chemical Structure

Phencarbamide HCl
Phencarbamide HCl
CAS#58-13-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 125450

Name: Phencarbamide HCl

CAS#: 58-13-9 (HCl)

Chemical Formula: C19H25ClN2OS

Exact Mass: 364.1400

Molecular Weight: 364.93

Elemental Analysis: C, 62.53; H, 6.91; Cl, 9.71; N, 7.68; O, 4.38; S, 8.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Phencarbamide hydrochloride; Fencarbamide hydrochloride; 58-13-9; Phenocarbamide hydrochloride; B77786C9A5
IUPAC/Chemical Name
S-(2-(diethylamino)ethyl) diphenylcarbamothioate hydrochloride
InChi Key
QHTWTHGLTISQOF-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H24N2OS.ClH/c1-3-20(4-2)15-16-23-19(22)21(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14H,3-4,15-16H2,1-2H3;1H
SMILES Code
Cl.CCN(CC)CCSC(=O)N(C1=CC=CC=C1)C2=CC=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 364.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: BOERGER HH. PHENKARBAMID, EIN NEUES SPASMOLYTIKUM IN KOMBINATION MIT DOLVIRAN [PHENCARBAMIDE, A NEW SPASMOLYTIC COMBINED WITH DOLVIRAN]. Ther Ggw. 1964 Jun;103:797-801. German. PMID: 14243633. 2: OBERSCHULTE H, RICHTER A. SPASMOLYSE IN DER GEBURTSHILFE. KLINISCHE ERFAHRUNGEN MIT PHENCARBAMID [SPASMOLYSIS IN OBSTETRICS: CLINICAL EXPERIENCE WITH PHENCARBAMIDE]. Med Welt. 1964 Sep 26;39:2086-8. German. PMID: 14303609. 3: WIRTH W. [On the pharmacology of the uterine action of phencarbamide]. Med Exp Int J Exp Med. 1963;8:107-15. German. PMID: 14001293. 4: BALKEN W. [On the clinical experiences with the spasmolytic Bayer 1355 (phencarbamide) in obstetrics]. Med Exp Int J Exp Med. 1963;8:116-24. German. PMID: 13966124. 5: Madan BR, Madan V, Pendse VK, Gupta RS. A study of the antiarrhythmic and local anaesthetic actions of phencarbamide. Arch Int Pharmacodyn Ther. 1970 May;185(1):53-65. PMID: 5470024. 6: Gupta RS, Khanna NK, Madan BR. Propranolol-bunolol and phencarbamide in chloroform-induced ventricular fibrillation in mice. Arch Int Pharmacodyn Ther. 1973 Jun;203(2):265-7. PMID: 4582610. 7: Madan BR, Gupta RS, Pendse VK, Madan V. Anticonvulsant effect of phencarbamide and its modification by reserpine and tranylcypromine. Arch Int Pharmacodyn Ther. 1971 Mar;190(1):155-8. PMID: 4994549. 8: Laurent A, Vilmer J. Dosage colorimétrique de la fencarbamide et de ses sels, chlorhydrate et naphtalène disulfonate [Colorimetric determination of phencarbamide and its hydrochloride and naphthalene disulfonate salts]. Ann Pharm Fr. 1971 Nov;29(11):569-71. French. PMID: 5138619. 9: Korte W, Beck KJ. Spasmolysewirkung von Phencarbamid auf das Collum uteri im Frühwochenbett [Spasmolytic effect of phencarbamide on the uterine cervix during early puerperium]. Med Klin. 1966 Aug 26;61(34):1341-3. German. PMID: 5995198. 10: PALM A. PRAKTISCHE ERFAHRUNGEN MIT DEM SPASMOLYTIKUM ESCORPAL IN DER GEBURTSHILFE [PRACTICAL EXPERIENCES WITH THE SPASMOLYTIC AGENT ESCORPAL IN OBSTETRICS]. Med Welt. 1965 Jan 30;19:277-8. German. PMID: 14271426.