Nortilidine | agonist | MOP receptor | CAS#38677-94-0

MedKoo Cat#: 125366 | Name: Nortilidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nortilidine is a selective agonist of the MOP receptor.

Chemical Structure

Nortilidine

CAS#38677-94-0

Theoretical Analysis

MedKoo Cat#: 125366

Name: Nortilidine

CAS#: 38677-94-0

Chemical Formula: C16H21NO2

Exact Mass: 259.1600

Molecular Weight: 259.35

Elemental Analysis: C, 74.10; H, 8.16; N, 5.40; O, 12.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Nortilidine; 38677-94-0; 7145G6817J; (-)-nortilidine; UNII-7145G6817J

IUPAC/Chemical Name

ethyl (1R,6S)-6-(methylamino)-3,6-dihydro-[1,1'-biphenyl]-1(2H)-carboxylate

InChi Key

PDJZPNKVLDWEKI-GOEBONIOSA-N

InChi Code

InChI=1S/C16H21NO2/c1-3-19-15(18)16(13-9-5-4-6-10-13)12-8-7-11-14(16)17-2/h4-7,9-11,14,17H,3,8,12H2,1-2H3/t14-,16+/m0/s1

SMILES Code

CCOC([C@@]1(C2=CC=CC=C2)CCC=C[C@@H]1NC)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 259.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Grün B, Merkel U, Riedel KD, Weiss J, Mikus G. Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine. Br J Clin Pharmacol. 2012 Nov;74(5):854-63. doi: 10.1111/j.1365-2125.2012.04261.x. PMID: 22381043; PMCID: PMC3495150. 2: Thierry C, Boeynaems JM, Paolo M. Actions of tilidine and nortilidine on cloned opioid receptors. Eur J Pharmacol. 2005 Jan 4;506(3):205-8. doi: 10.1016/j.ejphar.2004.11.020. Epub 2004 Dec 15. PMID: 15627429. 3: Hajda JP, Jähnchen E, Oie S, Trenk D. Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine. J Clin Pharmacol. 2002 Nov;42(11):1257-61. doi: 10.1177/009127002762491352. PMID: 12412825. 4: Weiss J, Sawa E, Riedel KD, Haefeli WE, Mikus G. In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6. Naunyn Schmiedebergs Arch Pharmacol. 2008 Sep;378(3):275-82. doi: 10.1007/s00210-008-0294-7. Epub 2008 May 31. PMID: 18516595. 5: Eichbaum C, Mathes K, Burhenne J, Markert C, Blank A, Mikus G. Pre-systemic elimination of tilidine: localization and consequences for the formation of the active metabolite nortilidine. Basic Clin Pharmacol Toxicol. 2015 Feb;116(2):129-33. doi: 10.1111/bcpt.12328. Epub 2014 Oct 7. PMID: 25223231.