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MedKoo Cat#: 201891 | Name: MK-0429
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-0429 is a potent and selective inhibitor of the αvβ3 integrin, which showed therapeutic effects on bone turnover disease in men with hormone-refractory prostate cancer (HRPC) and bone metastases. MK-0429 was safe and efficacious in significantly decreasing melanoma metastasis in the lungs. MK-0429 may be useful for the prevention of metastatic melanoma.

Chemical Structure

MK-0429
MK-0429
CAS#227963-15-7 (free base)

Theoretical Analysis

MedKoo Cat#: 201891

Name: MK-0429

CAS#: 227963-15-7 (free base)

Chemical Formula: C23H29N5O4

Exact Mass: 439.2220

Molecular Weight: 439.51

Elemental Analysis: C, 62.85; H, 6.65; N, 15.93; O, 14.56

Price and Availability

Size Price Availability Quantity
5mg USD 725.00 2 Weeks
10mg USD 1,250.00 2 Weeks
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Related CAS #
477841-10-4 (5 hydrate) 227963-15-7 (free base) 477841-08-0 (2 hydrate) 477841-09-1 (4 hydrate) 1125471-59-1 (0.5 hydrate)
Synonym
MK-0429; MK 0429; MK0429; L-000845704; L 000845704; L000845704; MK-429; MK 429; MK429
IUPAC/Chemical Name
(S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid
InChi Key
HGFOOLONGOBCMP-IBGZPJMESA-N
InChi Code
InChI=1S/C23H29N5O4/c1-32-20-9-7-17(15-25-20)19(14-21(29)30)28-13-12-27(23(28)31)11-3-5-18-8-6-16-4-2-10-24-22(16)26-18/h6-9,15,19H,2-5,10-14H2,1H3,(H,24,26)(H,29,30)/t19-/m0/s1
SMILES Code
O=C(O)C[C@@H](C1=CC=C(OC)N=C1)N2CCN(CCCC3=NC4=C(CCCN4)C=C3)C2=O
Appearance
white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
        

Preparing Stock Solutions

The following data is based on the product molecular weight 439.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pickarski M, Gleason A, Bednar B, Duong le T. Orally active αvβ3 integrin inhibitor MK-0429 reduces melanoma metastasis. Oncol Rep. 2015 Jun;33(6):2737-45. doi: 10.3892/or.2015.3910. Epub 2015 Apr 9. PubMed PMID: 25872534; PubMed Central PMCID: PMC4431436. 2: Rosenthal MA, Davidson P, Rolland F, Campone M, Xue L, Han TH, Mehta A, Berd Y, He W, Lombardi A. Evaluation of the safety, pharmacokinetics and treatment effects of an alpha(nu)beta(3) integrin inhibitor on bone turnover and disease activity in men with hormone-refractory prostate cancer and bone metastases. Asia Pac J Clin Oncol. 2010 Mar;6(1):42-8. doi: 10.1111/j.1743-7563.2009.01266.x. PubMed PMID: 20398037.