Synonym
DPA-713 HCl; DPA-713; DPA 713; DPA713;
IUPAC/Chemical Name
Pyrazolo(1,5-a)pyrimidine-3-acetamide, N,N-diethyl-2-(4-methoxyphenyl)-5,7-dimethyl- hydrochloride
InChi Key
FGUAYEZZBVGKCS-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H26N4O2.ClH/c1-6-24(7-2)19(26)13-18-20(16-8-10-17(27-5)11-9-16)23-25-15(4)12-14(3)22-21(18)25;/h8-12H,6-7,13H2,1-5H3;1H
SMILES Code
O=C(N(CC)CC)CC1=C2N=C(C)C=C(C)N2N=C1C3=CC=C(OC)C=C3.[H]Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
402.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lutanie E, Leung K.
N,N-Diethyl-2-2(2-(4-[11C]methoxyphenyl)-5,7-dimethyl-
pyrazolo(1,5-a)pyrimidin-3-yl)-acetamide. 2006 Apr 19 [updated 2010 Mar
11]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet].
Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013.
PMID: 20641518.
2: Akerele MI, Zein SA, Pandya S, Nikolopoulou A, Gauthier SA, Raj A,
Henchcliffe C, Mozley PD, Karakatsanis NA, Gupta A, Babich J, Nehmeh SA.
Population-based input function for TSPO quantification and kinetic modeling
with [11C]-DPA-713. EJNMMI Phys. 2021 Apr 29;8(1):39. doi:
10.1186/s40658-021-00381-8. PMID: 33914185; PMCID: PMC8085191.
3: Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K,
Hattori S, Shimoda N, Watanabe A, Kasuga K, Ikeuchi T, Takeda A, Sakurai T, Ito
K, Kato T. Involvement of inflammation in the medial temporal region in the
development of agitation in Alzheimer's disease: an in vivo positron emission
tomography study. Psychogeriatrics. 2023 Jan;23(1):126-135. doi:
10.1111/psyg.12915. Epub 2022 Nov 20. PMID: 36403981; PMCID: PMC10100091.
