Vicriviroc HCl | CCR5 receptor | CAS#541503-48-4

MedKoo Cat#: 125296 | Name: Vicriviroc HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vicriviroc or SCH 417690 is a potent and selective antagonist of the CCR5 receptor.

Chemical Structure

Vicriviroc HCl

CAS#541503-48-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 125296

Name: Vicriviroc HCl

CAS#: 541503-48-4 (HCl)

Chemical Formula: C28H39ClF3N5O2

Exact Mass: 569.2700

Molecular Weight: 570.10

Elemental Analysis: C, 58.99; H, 6.90; Cl, 6.22; F, 10.00; N, 12.28; O, 5.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

306296-47-9 (free base) 541503-81-5 (malate) 599179-03-0 (maleate) 541503-48-4 (HCl)

Synonym

Vicriviroc hydrochloride; 541503-48-4; Vicriviroc hydrochloride [MI]; 25SS1WQB7W;

IUPAC/Chemical Name

(4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone hydrochloride

InChi Key

ULGCLTGMZKAFMX-RIAYWLAYSA-N

InChi Code

InChI=1S/C28H38F3N5O2.ClH/c1-19-16-35(14-15-36(19)24(17-38-5)22-6-8-23(9-7-22)28(29,30)31)27(4)10-12-34(13-11-27)26(37)25-20(2)32-18-33-21(25)3;/h6-9,18-19,24H,10-17H2,1-5H3;1H/t19-,24-;/m0./s1

SMILES Code

Cl.COC[C@H](N1CCN(C[C@@H]1C)C2(C)CCN(CC2)C(=O)C3=C(C)N=CN=C3C)C4=CC=C(C=C4)C(F)(F)F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 570.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Liu AY, Zhang J, Anderson PL, Wagner T, Pan Z, Peda M, Gomez K, Beamer M, Jacobson C, Strizki J, Dezzutti CS, Piper JM; MTN-028 Protocol Team for the Microbicide Trials Network. Phase 1 Pharmacokinetic Trial of 2 Intravaginal Rings Containing Different Dose Strengths of Vicriviroc (MK-4176) and MK-2048. Clin Infect Dis. 2019 Mar 19;68(7):1129-1135. doi: 10.1093/cid/ciy652. PMID: 30289444; PMCID: PMC6424086.