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MedKoo Cat#: 125294 | Name: Phenadoxone HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenadoxone hydrochloride is one of some forty amino-ketones and amino-esters related to amidone. The compound is a very potent analgesic for the rat; by the subcutaneous route it is more active than either morphine or amidone.

Chemical Structure

Phenadoxone HCl
Phenadoxone HCl
CAS#20874-24-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 125294

Name: Phenadoxone HCl

CAS#: 20874-24-2 (HCl)

Chemical Formula: C23H30ClNO2

Exact Mass: 387.2000

Molecular Weight: 387.95

Elemental Analysis: C, 71.21; H, 7.79; Cl, 9.14; N, 3.61; O, 8.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
20874-24-2 (HCl) 467-84-5 (free base)
Synonym
Hepagin; Heptalgin; Supralgin; Phenadoxone hydrochloride; Heptazone hydrochloride
IUPAC/Chemical Name
6-morpholino-4,4-diphenylheptan-3-one hydrochloride
InChi Key
QGUPBYVADAJUNT-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H29NO2.ClH/c1-3-22(25)23(20-10-6-4-7-11-20,21-12-8-5-9-13-21)18-19(2)24-14-16-26-17-15-24;/h4-13,19H,3,14-18H2,1-2H3;1H
SMILES Code
Cl.CCC(=O)C(CC(C)N1CCOCC1)(C2=CC=CC=C2)C3=CC=CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 387.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: SHAW WH, JEFFERIES JP. The determination of phenadoxone. J Pharm Pharmacol. 1951 Nov;3(11):823-8. doi: 10.1111/j.2042-7158.1951.tb13126.x. PMID: 14898462. 2: BASIL B, EDGE ND, SOMERS GF. The pharmacology of phenadoxone or dl-6-morpholino-4:4-diphenyl-heptan-3-one hydrochloride. Br J Pharmacol Chemother. 1950 Mar;5(1):125-41. doi: 10.1111/j.1476-5381.1950.tb00582.x. PMID: 15405474; PMCID: PMC1509948. 3: VENTURI VM. Farmacologia del fenadoxone [Pharmacology of phenadoxone]. Farmaco Sci Tec. 1950 Mar-Apr;5(2):185-6. Undetermined Language. PMID: 15421358. 4: Robinson K, Smith RN. Methadone radioimmunoassay: two simple methods. J Pharm Pharmacol. 1983 Sep;35(9):566-70. doi: 10.1111/j.2042-7158.1983.tb04334.x. PMID: 6138405. 5: GREEN AF. Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion. Br J Pharmacol Chemother. 1959 Mar;14(1):26-34. doi: 10.1111/j.1476-5381.1959.tb00924.x. PMID: 13651575; PMCID: PMC1481834. 6: Paton WD. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. 1956. Br J Pharmacol. 1997 Feb;120(4 Suppl):123-31; discussion 121-2. doi: 10.1111/j.1476-5381.1997.tb06787.x. PMID: 9142400; PMCID: PMC3224282. 7: PATON WD. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br J Pharmacol Chemother. 1957 Mar;12(1):119-27. doi: 10.1111/j.1476-5381.1957.tb01373.x. PMID: 13413163; PMCID: PMC1509640.