VTP-27999 is a highly potent and selective renin inhibitor (IC50 = 0.47 nM). VTP-27999 demonstrated excellent selectivity over related and unrelated off-targets, >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.
MedKoo Cat#: 125293
Name: VTP-27999
CAS#: 942142-51-0 (free base)
Chemical Formula: C26H41ClN4O5
Exact Mass: 524.2800
Molecular Weight: 525.09
Elemental Analysis: C, 59.47; H, 7.87; Cl, 6.75; N, 10.67; O, 15.23
The following data is based on the product molecular weight 525.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
