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MedKoo Cat#: 125271 | Name: Phenylethylmalonamide hydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenylethylmalonamide (PEMA) is an important metabolite of primidone.

Chemical Structure

Phenylethylmalonamide hydrate
Phenylethylmalonamide hydrate
CAS#80866-90-6 (hydrate)

Theoretical Analysis

MedKoo Cat#: 125271

Name: Phenylethylmalonamide hydrate

CAS#: 80866-90-6 (hydrate)

Chemical Formula: C11H16N2O3

Exact Mass: 224.1200

Molecular Weight: 224.26

Elemental Analysis: C, 58.91; H, 7.19; N, 12.49; O, 21.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
80866-90-6 (hydrate) 7206-76-0 (free base)
Synonym
2-Ethyl-2-phenylmalonamide monohydrate; 80866-90-6; Phenylethylmalonamide hydrate; UNII-27L1MIN7YR; 27L1MIN7YR
IUPAC/Chemical Name
2-ethyl-2-phenylpropanediamide;hydrate
InChi Key
FZSBWHZDTUPYRX-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H14N2O2.H2O/c1-2-11(9(12)14,10(13)15)8-6-4-3-5-7-8;/h3-7H,2H2,1H3,(H2,12,14)(H2,13,15);1H2
SMILES Code
O=C(N)C(C1=CC=CC=C1)(CC)C(N)=O.[H]O[H]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 224.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baumel IP, Gallagher BB, Mattson RH. Phenylethylmalonamide (PEMA). An important metabolite of primidone. Arch Neurol. 1972 Jul;27(1):34-41. doi: 10.1001/archneur.1972.00490130036005. PMID: 4626105. 2: Calzetti S, Findley LJ, Pisani F, Richens A. Phenylethylmalonamide in essential tremor. A double-blind controlled study. J Neurol Neurosurg Psychiatry. 1981 Oct;44(10):932-4. doi: 10.1136/jnnp.44.10.932. PMID: 7031184; PMCID: PMC491180. 3: Yeary RA. Serum concentrations of primidone and its metabolites, phenylethylmalonamide and phenobarbital, in the dog. Am J Vet Res. 1980 Oct;41(10):1643-5. PMID: 7224290. 4: Streete JM, Berry DJ, Pettit LI, Newbery JE. Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs. Ther Drug Monit. 1986;8(2):161-5. doi: 10.1097/00007691-198606000-00006. PMID: 3088778. 5: Streete JM, Berry DJ, Jones JA, Groggin MJ. Clearance of phenylethylmalonamide during haemodialysis of a patient with renal failure. Ther Drug Monit. 1990 May;12(3):281-3. doi: 10.1097/00007691-199005000-00012. PMID: 2349613. 6: Pisani F, Richens A. Pharmacokinetics of phenylethylmalonamide (PEMA) after oral and intravenous administration. Clin Pharmacokinet. 1983 May- Jun;8(3):272-6. doi: 10.2165/00003088-198308030-00006. PMID: 6851372.