Norpethidine HBr | metabolite of pethidine | CAS#227470-64-6

MedKoo Cat#: 125268 | Name: Norpethidine HBr

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norpethidine is a metabolite of pethidine.

Chemical Structure

Norpethidine HBr

CAS#227470-64-6 (HBr)

Theoretical Analysis

MedKoo Cat#: 125268

Name: Norpethidine HBr

CAS#: 227470-64-6 (HBr)

Chemical Formula: C14H20BrNO2

Exact Mass: 313.0700

Molecular Weight: 314.22

Elemental Analysis: C, 53.51; H, 6.42; Br, 25.43; N, 4.46; O, 10.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

227470-64-6 (HBr) 24465-45-0 (HCl) 77-17-8 (free base)

Synonym

Norpethidine hydrobromide; Normeperidine hydrobromide; GT98GPM2FY; Pethidine intermediate B hydrobromide; UNII-GT98GPM2FY

IUPAC/Chemical Name

ethyl 4-phenylpiperidine-4-carboxylate;hydrobromide

InChi Key

VWUBXYBLJBUKCC-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H19NO2.BrH/c1-2-17-13(16)14(8-10-15-11-9-14)12-6-4-3-5-7-12;/h3-7,15H,2,8-11H2,1H3;1H

SMILES Code

O=C(C1(C2=CC=CC=C2)CCNCC1)OCC.[H]Br

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 314.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Plummer JL, Gourlay GK, Cmielewski PL, Odontiadis J, Harvey I. Behavioural effects of norpethidine, a metabolite of pethidine, in rats. Toxicology. 1995 Jan 6;95(1-3):37-44. doi: 10.1016/0300-483x(94)02871-q. PMID: 7825188. 2: Stone PA, Macintyre PE, Jarvis DA. Norpethidine toxicity and patient controlled analgesia. Br J Anaesth. 1993 Nov;71(5):738-40. doi: 10.1093/bja/71.5.738. PMID: 8251291. 3: Kul A, Ozdemir M, Sagirli O. Determination of pethidine of abuse and relevant metabolite norpethidine in urine by ultra-performance liquid chromatography- tandem mass spectrometry. J Pharm Biomed Anal. 2020 Jul 15;186:113320. doi: 10.1016/j.jpba.2020.113320. Epub 2020 Apr 23. PMID: 32387748. 4: McHugh GJ. Norpethidine accumulation and generalized seizure during pethidine patient-controlled analgesia. Anaesth Intensive Care. 1999 Jun;27(3):289-91. PMID: 10389564. 5: Zhang C, Li X, Xu Y, Wu T, Ren X, Liu D. Simultaneous determination of pethidine and norpethidine in mouse plasma by liquid chromatography-electrospray ionization source-mass spectrometry. J Anal Toxicol. 2013 Jul-Aug;37(6):351-6. doi: 10.1093/jat/bkt043. Epub 2013 May 29. PMID: 23719316. 6: Hogg MI, Wiener PC, Rosen M, Mapleson WW. Urinary excretion and metabolism of pethidine and norpethidine in the newborn. Br J Anaesth. 1977 Sep;49(9):891-9. doi: 10.1093/bja/49.9.891. PMID: 20914. 7: Knight B, Thomson N, Perry G. Seizures due to norpethidine toxicity. Aust N Z J Med. 2000 Aug;30(4):513. doi: 10.1111/j.1445-5994.2000.tb02064.x. PMID: 10985523.