2-chloro-2'-deoxyadenosine | 2CdA, Cladribine | antileukemic | CAS#2627-62-5

MedKoo Cat#: 125248 | Name: 2'-Chloro-2'-deoxyadenosine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

2-chloro-2'-deoxyadenosine (2CdA, Cladribine) is a new antileukemic drug.

Chemical Structure

2'-Chloro-2'-deoxyadenosine

CAS#2627-62-5

Theoretical Analysis

MedKoo Cat#: 125248

Name: 2'-Chloro-2'-deoxyadenosine

CAS#: 2627-62-5

Chemical Formula: C10H12ClN5O3

Exact Mass: 285.0600

Molecular Weight: 285.69

Elemental Analysis: C, 42.04; H, 4.23; Cl, 12.41; N, 24.51; O, 16.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

2627-62-5; 2'-Chloro-2'-deoxyadenosine; Adenosine, 2'-chloro-2'-deoxy-; 2'-Deoxy-2'-chloroadenosine; 3MR7O4XF3U

IUPAC/Chemical Name

(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-chloro-2-(hydroxymethyl)oxolan-3-ol

InChi Key

ADXUXRNLBYKGOA-QYYRPYCUSA-N

InChi Code

InChI=1S/C10H12ClN5O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5-,7-,10-/m1/s1

SMILES Code

O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@@H]1Cl

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 285.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fabianowska-Majewska K, Wyczechowska D. 2-Chloro-2'-deoxyadenosine (2CdA) biochemical aspects of antileukemic efficacy. Acta Pol Pharm. 1996 Jul- Aug;53(4):231-9. PMID: 9415193. 2: Davis JC Jr, Austin H 3rd, Boumpas D, Fleisher TA, Yarboro C, Larson A, Balow J, Klippel JH, Scott D. A pilot study of 2-chloro-2'-deoxyadenosine in the treatment of systemic lupus erythematosus-associated glomerulonephritis. Arthritis Rheum. 1998 Feb;41(2):335-43. doi: 10.1002/1529-0131(199802)41:2<335::AID-ART18>3.0.CO;2-O. PMID: 9485092. 3: Liliemark J, Juliusson G. 2-Chloro-2'-deoxyadenosine--clinical, biochemical and pharmacokinetic considerations. Arch Immunol Ther Exp (Warsz). 1994;42(1):7-10. PMID: 7503639. 4: Tarasiuk A, Skierski J, Kazimierczuk Z. Stability of 2-chloro-2'-deoxyadenosine at various pH and temperature. Arch Immunol Ther Exp (Warsz). 1994;42(1):13-5. PMID: 7503627.