Synonym
Ro 22-0654; Ro 220654; Ro-22-0654; Ro 220654; Ro 220654; Ro-220654;
IUPAC/Chemical Name
4-Amino-5-ethyl-3-thiophenecarboxylic acid methyl ester hydrochloride
InChi Key
IFDLYTVTWMMYFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H11NO2S.ClH/c1-3-6-7(9)5(4-12-6)8(10)11-2;/h4H,3,9H2,1-2H3;1H
SMILES Code
O=C(C1=CSC(CC)=C1N)OC.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
221.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Leinweber FJ, Szuna AJ, Loh AC, Williams TH, Sasso GJ, Bekersky I, Baggiolini E, Triscari J. Metabolism of the anti-obesity agent, 4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester hydrochloride, in rats and dogs. Xenobiotica. 1987 Dec;17(12):1405-14. PubMed PMID: 3439191.
2: Sullivan AC, Hogan S, Triscari J. New developments in pharmacological treatments for obesity. Ann N Y Acad Sci. 1987;499:269-76. Review. PubMed PMID: 3300486.
3: Stewart IC, Chapman BJ, Munro JF. Pharmacological approaches to the regulation of fat metabolism. Bibl Nutr Dieta. 1986;(39):16-26. PubMed PMID: 3541889.
4: Brooks MA, Lee TL. Determination of 4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester and its acid metabolite in plasma and urine by high-performance liquid chromatography. J Chromatogr. 1985 Dec 13;345(2):333-43. PubMed PMID: 4086602.
5: Drewnowski A, Grinker JA, Gruen R, Sullivan AC. Effects of inhibitors of carbohydrate absorption or lipid metabolism on meal patterns of Zucker rats. Pharmacol Biochem Behav. 1985 Nov;23(5):811-21. PubMed PMID: 3841213.
6: Yamamoto M, Fukuda N, Triscari J, Sullivan AC, Ontko JA. Decreased hepatic production of very low density lipoproteins following activation of fatty acid oxidation by Ro 22-0654. J Lipid Res. 1985 Oct;26(10):1196-204. PubMed PMID: 3934303.
7: Triscari J, Sullivan AC. Antiobesity effects of a novel lipid synthesis inhibitor (Ro 22-0654). Life Sci. 1984 Jun 18;34(25):2433-42. PubMed PMID: 6727577.
8: Triscari J, Sullivan AC. Anti-obesity activity of a novel lipid synthesis inhibitor. Int J Obes. 1984;8 Suppl 1:227-39. PubMed PMID: 6534895.
