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MedKoo Cat#: 526166 | Name: Ro 22-0654 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 22-0654 is a novel lipid synthesis inhibitor with antiobesity effects. Hepatic fatty acid synthesis was inhibited in vivo in a dose-dependent fashion with a duration of action of approximately 8 h. Adipose tissue fatty acid synthesis was also inhibited in vivo. Inhibition of fatty acid synthesis occurs without any apparent effect on several lipogenic enzymes, the tricarboxylic acid cycle, and the pentose phosphate shunt. Ro 22-0654 also stimulated fatty acid oxidation (in vitro) and lipolysis (in vivo). In long-term studies (2 months), Ro 22-0654 decreased body weight gain in Sprague Dawley and genetically-obese Zucker rats.

Chemical Structure

Ro 22-0654 HCl
Ro 22-0654 HCl
CAS#81741-99-3 (free base)

Theoretical Analysis

MedKoo Cat#: 526166

Name: Ro 22-0654 HCl

CAS#: 81741-99-3 (free base)

Chemical Formula: C8H12ClNO2S

Exact Mass: 185.0510

Molecular Weight: 221.70

Elemental Analysis: C, 43.34; H, 5.46; Cl, 15.99; N, 6.32; O, 14.43; S, 14.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
66319-20-8 (HCl) 81741-99-3 (free base)
Synonym
Ro 22-0654; Ro 220654; Ro-22-0654; Ro 220654; Ro 220654; Ro-220654;
IUPAC/Chemical Name
4-Amino-5-ethyl-3-thiophenecarboxylic acid methyl ester hydrochloride
InChi Key
IFDLYTVTWMMYFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H11NO2S.ClH/c1-3-6-7(9)5(4-12-6)8(10)11-2;/h4H,3,9H2,1-2H3;1H
SMILES Code
O=C(C1=CSC(CC)=C1N)OC.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 221.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Leinweber FJ, Szuna AJ, Loh AC, Williams TH, Sasso GJ, Bekersky I, Baggiolini E, Triscari J. Metabolism of the anti-obesity agent, 4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester hydrochloride, in rats and dogs. Xenobiotica. 1987 Dec;17(12):1405-14. PubMed PMID: 3439191. 2: Sullivan AC, Hogan S, Triscari J. New developments in pharmacological treatments for obesity. Ann N Y Acad Sci. 1987;499:269-76. Review. PubMed PMID: 3300486. 3: Stewart IC, Chapman BJ, Munro JF. Pharmacological approaches to the regulation of fat metabolism. Bibl Nutr Dieta. 1986;(39):16-26. PubMed PMID: 3541889. 4: Brooks MA, Lee TL. Determination of 4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester and its acid metabolite in plasma and urine by high-performance liquid chromatography. J Chromatogr. 1985 Dec 13;345(2):333-43. PubMed PMID: 4086602. 5: Drewnowski A, Grinker JA, Gruen R, Sullivan AC. Effects of inhibitors of carbohydrate absorption or lipid metabolism on meal patterns of Zucker rats. Pharmacol Biochem Behav. 1985 Nov;23(5):811-21. PubMed PMID: 3841213. 6: Yamamoto M, Fukuda N, Triscari J, Sullivan AC, Ontko JA. Decreased hepatic production of very low density lipoproteins following activation of fatty acid oxidation by Ro 22-0654. J Lipid Res. 1985 Oct;26(10):1196-204. PubMed PMID: 3934303. 7: Triscari J, Sullivan AC. Antiobesity effects of a novel lipid synthesis inhibitor (Ro 22-0654). Life Sci. 1984 Jun 18;34(25):2433-42. PubMed PMID: 6727577. 8: Triscari J, Sullivan AC. Anti-obesity activity of a novel lipid synthesis inhibitor. Int J Obes. 1984;8 Suppl 1:227-39. PubMed PMID: 6534895.