SKF-91488 HCl | CAS#68941-21-9 | methyltransferase inhibitor

MedKoo Cat#: 125223 | Name: SKF-91488 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SKF-91488 is a histamine N-methyltransferase inhibitor. It prevents the degradation of histamine, leading to increased histamine levels. SKF 91488 itself did not significantly alter PD or SCC values. Pretreatment with SKF 91488 significantly augmented PD and SCC induced by histamine. Amiloride did not significantly alter the augmentation by SKF 91488 in histamine-induced PD and SCC rises.

Chemical Structure

SKF-91488 HCl

CAS#68941-21-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 125223

Name: SKF-91488 HCl

CAS#: 68941-21-9 (HCl)

Chemical Formula: C7H19Cl2N3S

Exact Mass: 0.0000

Molecular Weight: 248.21

Elemental Analysis: C, 33.87; H, 7.72; Cl, 28.56; N, 16.93; S, 12.92

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,850.00	2 Weeks
2g	USD 5,950.00	2 Weeks

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Related CAS #

68643-23-2 (free base) 68941-21-9 (HCl)

Synonym

SKF 91488 dihydrochloride; SKF 91488 HCl; SKF91488 HCl; SKF 91488 dihydrochloride

IUPAC/Chemical Name

4-(dimethylamino)butyl carbamimidothioate dihydrochloride

InChi Key

NPLHSMBWWIIWAQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C7H17N3S.2ClH/c1-10(2)5-3-4-6-11-7(8)9;;/h3-6H2,1-2H3,(H3,8,9);2*1H

SMILES Code

CN(CCCCSC(=N)N)C.Cl.Cl

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 248.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jochem J, Zwirska-Korczala K, Rybus-Kalinowska B, Jagodzińska J, Korzonek- Szlacheta I. Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats. Pol J Pharmacol. 2002 May-Jun;54(3):237-44. PMID: 12398155. 2: Malmberg-Aiello P, Lamberti C, Ipponi A, Hänninen J, Ghelardini C, Bartolini A. Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301 U, in rodent antinociception. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):354-60. doi: 10.1007/pl00004954. PMID: 9089666. 3: Jochem J. Endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats--studies with histamine N-methyltransferase inhibitor SKF 91488. Inflamm Res. 2002 Nov;51(11):551-6. doi: 10.1007/pl00012426. PMID: 12540019. 4: Klein MC, Gertner SB. Evidence for a role of endogenous histamine in central cardiovascular regulation: inhibition of histamine-N-methyltransferase by SKF 91488. J Pharmacol Exp Ther. 1981 Feb;216(2):315-20. PMID: 6450831. 5: Nakazawa H, Sekizawa K, Morikawa M, Yamauchi K, Satoh M, Maeyama K, Watanabe T, Sasaki H. Viral respiratory infection causes airway hyperresponsiveness and decreases histamine N-methyltransferase activity in guinea pigs. Am J Respir Crit Care Med. 1994 May;149(5):1180-5. doi: 10.1164/ajrccm.149.5.8173757. PMID: 8173757.