Synonym
F-SLOH; F SLOH; FSLOH
IUPAC/Chemical Name
(E)-4-(2-(6-fluoro-9-(2-(2-methoxyethoxy)ethyl)-9H-carbazol-3-yl)vinyl)-1-(2-hydroxyethyl)quinolin-1-ium chloride
InChi Key
ZUXVASZSUFMGKK-UHFFFAOYSA-M
InChi Code
InChI=1S/C30H30FN2O3.ClH/c1-35-18-19-36-17-15-33-29-10-7-22(20-26(29)27-21-24(31)9-11-30(27)33)6-8-23-12-13-32(14-16-34)28-5-3-2-4-25(23)28;/h2-13,20-21,34H,14-19H2,1H3;1H/q+1;/p-1
SMILES Code
COCCOCCN1C(C=CC(/C=C/C2=C(C=CC=C3)C3=[N+](CCO)C=C2)=C4)=C4C5=CC(F)=CC=C51.[Cl-]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
F-SLOH promotes the clearance of C-terminal fragment 15 (CTF15) of APP and Paired helical filaments of Tau (PHF1) in stable cell models via the activation of transcription factor EB (TFEB). Moreover, F-SLOH promotes ALP and lysosomal biogenesis for the clearance of soluble, insoluble Aβ, and phospho Tau. Our results unambiguously reveal effective etiological capabilities of theranostic F-SLOH to target and intervene multiple neuropathological changes in AD mouse models. Therefore, F-SLOH demonstrates tremendous therapeutic potential for treating AD in its early stage.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
521.03
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Iyaswamy A, Wang X, Krishnamoorthi S, Kaliamoorthy V, Sreenivasmurthy SG, Kumar Durairajan SS, Song JX, Tong BC, Zhu Z, Su CF, Liu J, Cheung KH, Lu JH, Tan JQ, Li HW, Wong MS, Li M. Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models. Redox Biol. 2022 May;51:102280. doi: 10.1016/j.redox.2022.102280. Epub 2022 Mar 8. PMID: 35286997; PMCID: PMC8921490.
2: Li Y, Xu D, Sun A, Ho SL, Poon CY, Chan HN, Ng OTW, Yung KKL, Yan H, Li HW, Wong MS. Fluoro-substituted cyanine for reliable in vivo labelling of amyloid-β oligomers and neuroprotection against amyloid-β induced toxicity. Chem Sci. 2017 Dec 1;8(12):8279-8284. doi: 10.1039/c7sc03974c. Epub 2017 Oct 9. PMID: 29619173; PMCID: PMC5858019.
