MedKoo Cat#: 125128 | Name: DEG-77
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DEG-77 is a cereblon-dependent degrader of IKZF2 and casein kinase 1α (CK1α).

Chemical Structure

DEG-77
DEG-77
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125128

Name: DEG-77

CAS#: N/A

Chemical Formula: C24H21N3O6

Exact Mass: 447.1400

Molecular Weight: 447.14

Elemental Analysis: Elemental Analysis: C, 64.42; H, 4.73; N, 9.39; O, 21.45

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
25mg USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
DEG-77; DEG 77; DEG77
IUPAC/Chemical Name
N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)-8-methoxy-2H-chromene-3-carboxamide
InChi Key
ZFAKJMUJUNDGEI-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H21N3O6/c1-32-19-4-2-3-13-9-15(12-33-21(13)19)22(29)25-16-5-6-17-14(10-16)11-27(24(17)31)18-7-8-20(28)26-23(18)30/h2-6,9-10,18H,7-8,11-12H2,1H3,(H,25,29)(H,26,28,30)
SMILES Code
O=C1CCC(N2C(C3=CC=C(NC(C4=CC(C=CC=C5OC)=C5OC4)=O)C=C3C2)=O)C(N1)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 447.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Park SM, Miyamoto DK, Han GYQ, Chan M, Curnutt NM, Tran NL, Velleca A, Kim JH, Schurer A, Chang K, Xu W, Kharas MG, Woo CM. Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells. Cancer Cell. 2023 Apr 10;41(4):726-739.e11. doi: 10.1016/j.ccell.2023.02.010. Epub 2023 Mar 9. PMID: 36898380; PMCID: PMC10466730.