MedKoo Cat#: 125125 | Name: T1-44
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

T1-44 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5).

Chemical Structure

T1-44
T1-44
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125125

Name: T1-44

CAS#: N/A

Chemical Formula: C27H38N6O2

Exact Mass: 478.3100

Molecular Weight: 478.64

Elemental Analysis: C, 67.75; H, 8.00; N, 17.56; O, 6.69

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
25mg USD 1,050.00 2 Weeks
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Related CAS #
No Data
Synonym
T1-44; T144; T1 44
IUPAC/Chemical Name
2-(cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(4-methylpiperazin-1-yl)isonicotinamide
InChi Key
KSSPASCZXJGUBO-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H38N6O2/c1-31-11-13-33(14-12-31)26-16-22(15-25(30-26)29-23-7-4-8-23)27(35)28-17-24(34)19-32-10-9-20-5-2-3-6-21(20)18-32/h2-3,5-6,15-16,23-24,34H,4,7-14,17-19H2,1H3,(H,28,35)(H,29,30)
SMILES Code
CN1CCN(C2=NC(NC3CCC3)=CC(C(NCC(O)CN4CCC(C=CC=C5)=C5C4)=O)=C2)CC1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 478.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Hong E, Barczak W, Park S, Heo JS, Ooshima A, Munro S, Hong CP, Park J, An H, Park JO, Park SH, La Thangue NB, Kim SJ. Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors. Cell Death Dis. 2023 Feb 10;14(2):93. doi: 10.1038/s41419-023-05630-5. PMID: 36765032; PMCID: PMC9918730.