ERAS-5024 is a Potent and Selective KRAS G12D Inhibitor. ERAS-5024 inhibited ERK1/2 phosphorylation and cell proliferation in three-dimensional Cell-Titer Glo assays in AsPC-1 PDAC cells with single-digit nanomolar potency and caused tumor regression in the in vivo efficacy studies.
MedKoo Cat#: 124937
Name: ERAS-5024
CAS#: N/A
Chemical Formula: C32H29F6N7OS
Exact Mass: 673.2100
Molecular Weight: 673.68
Elemental Analysis: C, 57.05; H, 4.34; F, 16.92; N, 14.55; O, 2.37; S, 4.76
The following data is based on the product molecular weight 673.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
