Synonym
NOTA-NFB; NOTANFB; NOTA NFB
SMILES Code
O=C(NN[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C([Nal](SS[Cys](N[C@@H](CCCNC(N)=N)C(N)=O)N[C@H]1CCCNC(N)=O)N[C@@H](CS)C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C([Lys](N3CCC[C@H]3C([Arg](N[C@@H](CC4=CC=C(O)C=C4)C=O)C1=O)=O)[DLys])=O)CCCNC(N)=O)=O)=O)=O)=O)CN5CCN(CC(O)=O)CCN(CC(O)=O)CC5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis, and is upregulated in several tumor cell types. CXCR4 expression is correlated with tumor aggressiveness and high metastatic potential. Unmodified T140 binds non-specifically to red blood cells (RBCs); replacing the fluoro-benzoyl group with NOTA (NOTA-NFB) prevents the RBC binding almost entirely, while only minimally reducing the binding to CXCR4-positive tumor cells.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
2,405.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Leung K. 64Cu-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic
acid-Arg-Arg-Natl-Cys-Tyr-Cit-Lys-d-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-NH2.
2011 Nov 15 [updated 2012 Feb 9]. In: Molecular Imaging and Contrast Agent
Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology
Information (US); 2004–2013. PMID: 22338195.
2: Wang Z, Zhang M, Wang L, Wang S, Kang F, Li G, Jacobson O, Niu G, Yang W,
Wang J, Chen X. Prospective Study of (68)Ga-NOTA-NFB: Radiation Dosimetry in
Healthy Volunteers and First Application in Glioma Patients. Theranostics. 2015
Apr 28;5(8):882-9. doi: 10.7150/thno.12303. PMID: 26000059; PMCID: PMC4440444.
3: Leung K. 64Cu-1,4,7-Triazacyclononane-1,4,7-triacetic acid-Arg-
Arg-Natl-Cys-Tyr-Cit-Lys-d-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-NH2. 2011 Nov
15 [updated 2012 Feb 9]. In: Molecular Imaging and Contrast Agent Database
(MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information
(US); 2004–2013. PMID: 22338192.
4: Jacobson O, Weiss ID, Szajek LP, Niu G, Ma Y, Kiesewetter DO, Peled A, Eden
HS, Farber JM, Chen X. Improvement of CXCR4 tracer specificity for PET imaging.
J Control Release. 2012 Jan 30;157(2):216-23. doi:
10.1016/j.jconrel.2011.09.076. Epub 2011 Sep 22. PMID: 21964282; PMCID:
PMC3259211.
