ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. In vitro studies have demonstrated that ND-011992 effectively inhibits these enzymes with IC₅₀ values in the low micromolar range. Specifically, it inhibits respiratory complex I with an IC₅₀ of 0.12 µM, and both cytochrome bd oxidases with IC₅₀ values of 0.63 µM and 1.3 µM, respectively. Additionally, ND-011992 has been shown to enhance the bactericidal activity of other antibiotics, such as Q203, against antibiotic-tolerant M. tuberculosis strains. This combination therapy has demonstrated improved efficacy in reducing bacterial load in animal models
MedKoo Cat#: 124854
Name: ND-011992
CAS#: 2446880-46-0
Chemical Formula: C21H14F3N3O
Exact Mass: 381.1089
Molecular Weight: 381.36
Elemental Analysis: C, 66.14; H, 3.70; F, 14.95; N, 11.02; O, 4.20
The following data is based on the product molecular weight 381.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
