NRAS-G4 inhibitor 18 binds reversibly to the NRAS-G4 structure with submicromolar affinity. NRAS-G4 inhibitor 18 inhibits the translation of NRAS via stabilizing the NRAS-G4 in vitro but shows only moderate effects on the NRAS levels in cellulo.
MedKoo Cat#: 150055
Name: NRAS-G4 inhibitor 18
CAS#: N/A
Chemical Formula: C25H22N6O3S
Exact Mass: 486.1470
Molecular Weight: 486.55
Elemental Analysis: C, 61.72; H, 4.56; N, 17.27; O, 9.86; S, 6.59
The following data is based on the product molecular weight 486.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
