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MedKoo Cat#: 124844 | Name: Mitaplatin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mitaplatin is a PDK inhibitor.

Chemical Structure

Mitaplatin
Mitaplatin
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124844

Name: Mitaplatin

CAS#: N/A

Chemical Formula: C4H8Cl6N2O4Pt

Exact Mass: 552.8300

Molecular Weight: 555.90

Elemental Analysis: C, 8.64; H, 1.45; Cl, 38.26; N, 5.04; O, 11.51; Pt, 35.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Mitaplatin; Mita-platin; Mita platin
IUPAC/Chemical Name
N/A
InChi Key
SFQVINCQRGGSPW-UHFFFAOYSA-J
InChi Code
InChI=1S/2C2H2Cl2O2.2ClH.2H3N.Pt/c2*3-1(4)2(5)6;;;;;/h2*1H,(H,5,6);2*1H;2*1H3;/q;;;;;;+4/p-4
SMILES Code
O=C(C(Cl)Cl)O[Pt](Cl)([NH3])(Cl)([NH3])OC(C(Cl)Cl)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 555.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dhar S, Lippard SJ. Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22199-204. doi: 10.1073/pnas.0912276106. Epub 2009 Dec 10. PMID: 20007777; PMCID: PMC2799774. 2: Xue X, You S, Zhang Q, Wu Y, Zou GZ, Wang PC, Zhao YL, Xu Y, Jia L, Zhang X, Liang XJ. Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction. Mol Pharm. 2012 Mar 5;9(3):634-44. doi: 10.1021/mp200571k. Epub 2012 Feb 13. PMID: 22289032; PMCID: PMC3310394. 3: Johnstone TC, Kulak N, Pridgen EM, Farokhzad OC, Langer R, Lippard SJ. Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties. ACS Nano. 2013 Jul 23;7(7):5675-83. doi: 10.1021/nn401905g. Epub 2013 May 22. PMID: 23697579; PMCID: PMC3722263.

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BIRT-377

BIRT-377