JNJ-40929837 succinate | CAS#1191044-47-9 | LTA4 hydrolase inhibitor

MedKoo Cat#: 124829 | Name: JNJ-40929837 succinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-40929837 is an oral inhibitor of LTA4 hydrolase, which catalyzes LTB4 production.

Chemical Structure

JNJ-40929837 succinate

CAS#1191044-47-9 (succinate)

Theoretical Analysis

MedKoo Cat#: 124829

Name: JNJ-40929837 succinate

CAS#: 1191044-47-9 (succinate)

Chemical Formula: C26H30N4O6S

Exact Mass: 526.1900

Molecular Weight: 526.61

Elemental Analysis: C, 59.30; H, 5.74; N, 10.64; O, 18.23; S, 6.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1191044-47-9 (succinate) 1191044-42-4 (free base)

Synonym

JNJ-40929837 succinate; J43PP874SF; UNII-J43PP874SF; 1191044-47-9; SCHEMBL1888476

IUPAC/Chemical Name

N-(8-(4-(thiazolo[4,5-b]pyridin-2-yloxy)benzyl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide succinate

InChi Key

ASCCNTPYAKLKGG-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H24N4O2S.C4H6O4/c1-14(27)24-16-11-17-6-7-18(12-16)26(17)13-15-4-8-19(9-5-15)28-22-25-21-20(29-22)3-2-10-23-21;5-3(6)1-2-4(7)8/h2-5,8-10,16-18H,6-7,11-13H2,1H3,(H,24,27);1-2H2,(H,5,6)(H,7,8)

SMILES Code

CC(=O)NC1CC2CCC(C1)N2CC3=CC=C(C=C3)OC4=NC5=C(S4)C=CC=N5.C(CC(=O)O)C(=O)O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 526.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Barchuk W, Lambert J, Fuhr R, Jiang JZ, Bertelsen K, Fourie A, Liu X, Silkoff PE, Barnathan ES, Thurmond R. Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma. Pulm Pharmacol Ther. 2014 Oct;29(1):15-23. doi: 10.1016/j.pupt.2014.06.003. Epub 2014 Jul 10. PMID: 25018015. 2: Ward PD, La D. Testicular distribution and toxicity of a novel LTA4H inhibitor in rats. Toxicol Appl Pharmacol. 2014 Jul 1;278(1):26-30. doi: 10.1016/j.taap.2014.04.012. Epub 2014 Apr 22. PMID: 24769091.