Synonym
VU534; VU-534; VU 534
IUPAC/Chemical Name
N-(5,7-dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide
InChi Key
RLHUIVPGYWWIQZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H22FN3O3S2/c1-13-11-14(2)19-18(12-13)23-21(29-19)24-20(26)15-7-9-25(10-8-15)30(27,28)17-5-3-16(22)4-6-17/h3-6,11-12,15H,7-10H2,1-2H3,(H,23,24,26)
SMILES Code
CC1=CC(C)=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
May 7, 2024- Product VU534 Patent licensing News
MedKoo is excited to announce the licensing of patents of the novel compound VU534 from Vanderbilt University. VU534, a breakthrough compound, is now featured on our website at https://medkoo.com/products/55763. VU534 is a NAPE-PLD activator with an EC50 of 0.30 μM. Several lines of evidence suggest that reduced NAPE-PLD activity could contribute to cardiometabolic diseases. VU534 was shown to increase efferocytosis by bone-marrow derived macrophages isolated from wild-type mice, while efferocytosis was significantly reduced in Napepld-/- BMDM or after Nape-pld inhibition. . This groundbreaking product is safeguarded by patents including World Patent WO 2023/201014 A1
Preparing Stock Solutions
The following data is based on the
product
molecular weight
447.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zarrow JE, Alli-Oluwafuyi AM, Youwakim CM, Kim K, Jenkins AN, Suero IC, Jones
MR, Mashhadi Z, Mackie K, Waterson AG, Doran AC, Sulikowski GA, Davies SS. Small
Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem
Biol. 2023 Aug 18;18(8):1891-1904. doi: 10.1021/acschembio.3c00401. Epub 2023
Aug 2. PMID: 37531659; PMCID: PMC10443532.
2: Zarrow JE, Alli-Oluwafuyi AM, Youwakim CM, Kim K, Jenkins AN, Suero IC, Jones
MR, Mashhadi Z, Mackie KP, Waterson AG, Doran AC, Sulikowski GA, Davies SS.
Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages.
bioRxiv [Preprint]. 2023 Feb 28:2023.01.25.525554. doi:
10.1101/2023.01.25.525554. Update in: ACS Chem Biol. 2023 Aug
18;18(8):1891-1904. doi: 10.1021/acschembio.3c00401. PMID: 36747693; PMCID:
PMC9900783.
