Dazostinag, also known as TAK-676, is a novel systemic STING agonist demonstrating robust activation of innate and adaptive immune activity resulting in durable antitumor responses within multiple syngeneic tumor models. TAK-676 dose-dependently triggers activation of the STING signaling pathway and activation of type I interferons. Furthermore, TAK-676 is a highly potent modulator of both the innate and adaptive immune system and that it promotes the activation of dendritic cells, natural killer cells, and T cells in preclinical models. In syngeneic murine tumor models in vivo, TAK-676 induces dose-dependent cytokine responses and increases the activation and proliferation of immune cells within the TME and tumor-associated lymphoid tissue.
MedKoo Cat#: 124776
Name: Dazostinag disodium
CAS#: 2553413-93-5 (sodium)
Chemical Formula: C21H20F2N8Na2O10P2S2
Exact Mass: 754.0000
Molecular Weight: 754.48
Elemental Analysis: C, 33.43; H, 2.67; F, 5.04; N, 14.85; Na, 6.09; O, 21.21; P, 8.21; S, 8.50
The following data is based on the product molecular weight 754.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
