YPD-29B | PD-1/PD-L1 | small-moleculeinhibitor

MedKoo Cat#: 124682 | Name: YPD-29B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YPD-29B is a PD-1/PD-L1small-moleculeinhibitor.

Chemical Structure

YPD-29B

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124682

Name: YPD-29B

CAS#: N/A

Chemical Formula: C30H31BrN2O5

Exact Mass: 578.1400

Molecular Weight: 579.49

Elemental Analysis: C, 62.18; H, 5.39; Br, 13.79; N, 4.83; O, 13.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

78V6PF4YBX; YPD-29B; YPD29B; YPD 29B

IUPAC/Chemical Name

((4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-methyl-2-(pyridin-3-ylmethoxy)cyclohexa-2,4-dien-1-yl)methyl)serine

InChi Key

ZMRIYGHBGFFYKQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H31BrN2O5/c1-20-13-24(16-33-26(17-34)30(35)36)28(37-18-21-7-6-12-32-15-21)14-27(20)38-19-23-10-5-11-25(29(23)31)22-8-3-2-4-9-22/h2-12,14-15,24,26,33-34H,13,16-19H2,1H3,(H,35,36)

SMILES Code

CC1=C(OCC2=C(Br)C(C3=CC=CC=C3)=CC=C2)C=C(OCC4=CN=CC=C4)C(CNC(C(O)=O)CO)C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 579.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lai F, Ji M, Huang L, Wang Y, Xue N, Du T, Dong K, Yao X, Jin J, Feng Z, Chen X. YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer. Acta Pharm Sin B. 2022 Jun;12(6):2845-2858. doi: 10.1016/j.apsb.2022.02.031. Epub 2022 Mar 4. Erratum in: Acta Pharm Sin B. 2023 Jul;13(7):3178-3179. PMID: 35755282; PMCID: PMC9214057. 2: Jiang J, Zou X, Liu Y, Liu X, Dong K, Yao X, Feng Z, Chen X, Sheng L, Li Y. Simultaneous Determination of a Novel PD-L1 Inhibitor, IMMH-010, and Its Active Metabolite, YPD-29B, in Rat Biological Matrices by Polarity-Switching Liquid Chromatography-Tandem Mass Spectrometry: Application to ADME Studies. Front Pharmacol. 2021 Jun 21;12:677120. doi: 10.3389/fphar.2021.677120. PMID: 34234673; PMCID: PMC8256334. 3: Lai F, Ji M, Huang L, Wang Y, Xue N, Du T, Dong K, Yao X, Jin J, Feng Z, Chen X. Erratum: Author correction to "YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer" [Acta Pharmaceutica Sinica B 12 (2022) 2845-2858]. Acta Pharm Sin B. 2023 Jul;13(7):3178-3179. doi: 10.1016/j.apsb.2023.05.003. Epub 2023 May 9. Erratum for: Acta Pharm Sin B. 2022 Jun;12(6):2845-2858. PMID: 37521865; PMCID: PMC10372818. 4: Wang Y, Liu X, Zou X, Wang S, Luo L, Liu Y, Dong K, Yao X, Li Y, Chen X, Sheng L. Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell Death Ligand 1 Inhibitor Prodrug. Pharmaceutics. 2021 Apr 21;13(5):598. doi: 10.3390/pharmaceutics13050598. PMID: 33919384; PMCID: PMC8143347.