SH491 is a potent antiosteoporosis Agent. SH491 (IC50 = 11.8 nM) showed the high potency with 100% inhibition at 0.1 μM and 44.4% inhibition at an even lower concentration of 0.01 μM, which was much more potent than the lead compound PPD (IC50 = 10.3 μM). SH491 also exhibited a notable impact on the osteoblastogenesis of MC3T3-E1 preosteoblasts. SH491 inhibits the expression of osteoclastogenesis-related marker genes and proteins, including TRAP, CTSK, MMP-9, and ATPase v0d2. In vivo, SH491 could dramatically decrease the ovariectomy-induced osteoclast activity and relieve osteoporosis obviously.
MedKoo Cat#: 124681
Name: SH491
CAS#: N/A
Chemical Formula: C33H50N2O
Exact Mass: 490.3900
Molecular Weight: 490.78
Elemental Analysis: C, 80.76; H, 10.27; N, 5.71; O, 3.26
The following data is based on the product molecular weight 490.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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