Londamocitinib | CAS#2241039-81-4 | Janus kinase inhibitor | JAK1

MedKoo Cat#: 140234 | Name: Londamocitinib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Londamocitinib, also known as AZD4604, is a highly potent and selective JAK1 inhibitor (IC50 = 0.54 nM). AZD4604 possesses sub-nanomolar potency for JAK1 and is >1000-fold selective over JAK2, JAK3, and TYK2 as determined by the ratio of JAK2, JAK3, and TYK2 IC50s, respectively, over JAK1 IC50.

Chemical Structure

Londamocitinib

CAS#2241039-81-4

Theoretical Analysis

MedKoo Cat#: 140234

Name: Londamocitinib

CAS#: 2241039-81-4

Chemical Formula: C28H31F2N7O4S

Exact Mass: 599.2126

Molecular Weight: 599.66

Elemental Analysis: C, 56.08; H, 5.21; F, 6.34; N, 16.35; O, 10.67; S, 5.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Londamocitinib; JAK1-IN-7; AZD4604; 2241039-81-4; AZD-4604; JAC34RRR7S

IUPAC/Chemical Name

(2R)-N-(3-{5-fluoro-2-[2-fluoro-3-(methanesulfonyl)anilino]pyrimidin-4-yl}-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide

InChi Key

JNUZADQZHYFJGW-JOCHJYFZSA-N

InChi Code

InChI=1S/C28H31F2N7O4S/c1-36-10-12-37(13-11-36)22(16-41-2)27(38)33-21-8-4-6-17-18(14-31-26(17)21)25-19(29)15-32-28(35-25)34-20-7-5-9-23(24(20)30)42(3,39)40/h4-9,14-15,22,31H,10-13,16H2,1-3H3,(H,33,38)(H,32,34,35)/t22-/m1/s1

SMILES Code

O=C(NC1=CC=CC2=C1NC=C2C3=NC(NC4=CC=CC(S(=O)(C)=O)=C4F)=NC=C3F)[C@H](N5CCN(C)CC5)COC

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 599.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nilsson M, Rhedin M, Hendrickx R, Berglund S, Piras A, Blomgran P, Cavallin A, Collins M, Dahl G, Dekkak B, Ericsson T, Hagberg N, Holmberg AA, Leffler A, Lundqvist AJ, Markou T, Pinkerton J, Rönnblom L, Siu S, Taylor V, Wennberg T, Zervas D, Laurence ADJ, Mitra S, Belvisi MG, Birrell M, Borde A. Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma. Drug Des Devel Ther. 2022 Aug 31;16:2901-2917. doi: 10.2147/DDDT.S354291. PMID: 36068788; PMCID: PMC9441147. 2: Nilsson M, Berggren K, Berglund S, Cerboni S, Collins M, Dahl G, Elmqvist D, Grimster NP, Hendrickx R, Johansson JR, Kettle JG, Lepistö M, Rhedin M, Smailagic A, Su Q, Wennberg T, Wu A, Österlund T, Naessens T, Mitra S. Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization. J Med Chem. 2023 Sep 22. doi: 10.1021/acs.jmedchem.3c00554. Epub ahead of print. PMID: 37738648.