PB131 is a novel brain-permeable HDAC6 inhibitor, exhibiting potent binding affinity and selectivity against HDAC6. It has an IC50 value of 1.8 nM and more than 116-fold selectivity over other HDAC isoforms.
MedKoo Cat#: 130547
Name: PB131
CAS#: PB131
Chemical Formula: C16H16FN3O2
Exact Mass: 301.1227
Molecular Weight: 301.32
Elemental Analysis: C, 63.78; H, 5.35; F, 6.31; N, 13.95; O, 10.62
The following data is based on the product molecular weight 301.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
