MedKoo Cat#: 124608 | Name: EN450
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB.

Chemical Structure

EN450
EN450
CAS#793719-01-4

Theoretical Analysis

MedKoo Cat#: 124608

Name: EN450

CAS#: 793719-01-4

Chemical Formula: C11H13ClN2O3S

Exact Mass: 288.0335

Molecular Weight: 288.75

Elemental Analysis: C, 45.76; H, 4.54; Cl, 12.28; N, 9.70; O, 16.62; S, 11.10

Price and Availability

Size Price Availability Quantity
100mg USD 1,150.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 3,250.00 2 Weeks
1g USD 4,650.00 2 Weeks
2g USD 6,950.00 2 Weeks
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Related CAS #
No Data
Synonym
EN450; EN-450; EN 450; starbld0003560; GTPL12636
IUPAC/Chemical Name
N-(2-chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide
InChi Key
OXFXDOLAQBMOPH-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H13ClN2O3S/c1-4-11(15)13-10-7-8(5-6-9(10)12)18(16,17)14(2)3/h4-7H,1H2,2-3H3,(H,13,15)
SMILES Code
O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 288.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: King EA, Cho Y, Hsu NS, Dovala D, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB. Cell Chem Biol. 2023 Apr 20;30(4):394-402.e9. doi: 10.1016/j.chembiol.2023.02.008. Epub 2023 Mar 9. PMID: 36898369; PMCID: PMC10121878. 2: Shirley R, Black L. Alkali activated solidification/stabilisation of air pollution control residues and co-fired pulverised fuel ash. J Hazard Mater. 2011 Oct 30;194:232-42. doi: 10.1016/j.jhazmat.2011.07.100. Epub 2011 Aug 5. PMID: 21880422.