Synonym
Z-LE(OMe)HD(OMe)-FMK; Z-LEHD-FMK . Z-Leu-Glu(OMe)-His-Asp(OMe)-CH₂F.
IUPAC/Chemical Name
methyl (5S,8S,11S,14S)-11-((1H-imidazol-5-yl)methyl)-14-(2-fluoroacetyl)-5-isobutyl-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
InChi Key
YXRKBEPGVHOXSV-QORCZRPOSA-N
InChi Code
InChI=1S/C32H43FN6O10/c1-19(2)12-24(39-32(46)49-17-20-8-6-5-7-9-20)30(44)36-22(10-11-27(41)47-3)29(43)38-25(13-21-16-34-18-35-21)31(45)37-23(26(40)15-33)14-28(42)48-4/h5-9,16,18-19,22-25H,10-15,17H2,1-4H3,(H,34,35)(H,36,44)(H,37,45)(H,38,43)(H,39,46)/t22-,23-,24-,25-/m0/s1
SMILES Code
O=C(OC)CC[C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
690.73
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mullani N, Singh MK, Sharma A, Rameshbabu K, Manik RS, Palta P, Singla SK,
Chauhan MS. Caspase-9 inhibitor Z-LEHD-FMK enhances the yield of in vitro
produced buffalo (Bubalus bubalis) pre-implantation embryos and alters cellular
stress response. Res Vet Sci. 2016 Feb;104:4-9. doi: 10.1016/j.rvsc.2015.11.008.
Epub 2015 Nov 14. PubMed PMID: 26850530.
2: Colak A, Karaoğlan A, Barut S, Köktürk S, Akyildiz AI, Taşyürekli M.
Neuroprotection and functional recovery after application of the caspase-9
inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury. J Neurosurg
Spine. 2005 Mar;2(3):327-34. PubMed PMID: 15796358.
3: Ozoren N, Kim K, Burns TF, Dicker DT, Moscioni AD, El-Deiry WS. The caspase 9
inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer
cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer
Res. 2000 Nov 15;60(22):6259-65. PubMed PMID: 11103780.
