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MedKoo Cat#: 124472 | Name: Lenacapavir sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lenacapavir, also known as GS-6207, is a HIV-1 capsid inhibitor. Lenacapavir shows anti-HIV activity. Lenacapavir displays a mean EC50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells (PBMCs). Lenacapavir demonstrated picomolar potency in vitro with no cross resistance to existing antiretroviral classes and potent antiviral activity in persons with HIV-1. In persons with HIV-1, there was no preexisting resistance to lenacapavir regardless of treatment history.

Chemical Structure

Lenacapavir sodium
Lenacapavir sodium
CAS#2283356-12-5 (sodium)

Theoretical Analysis

MedKoo Cat#: 124472

Name: Lenacapavir sodium

CAS#: 2283356-12-5 (sodium)

Chemical Formula: C39H31ClF10N7NaO5S2

Exact Mass: 989.1300

Molecular Weight: 990.26

Elemental Analysis: C, 47.30; H, 3.16; Cl, 3.58; F, 19.19; N, 9.90; Na, 2.32; O, 8.08; S, 6.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2283356-18-1 (HCl) 2189684-44-2 (free) 2283356-12-5 (sodium)
Synonym
Lenacapavir sodium; GS-HIV Sodium; GS-HIV Na; BDT58WJ9WE; Lenacapavir sodium [USAN]
IUPAC/Chemical Name
sodium;[4-chloro-7-[2-[(1S)-2-(3,5-difluorophenyl)-1-[[2-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]acetyl]amino]ethyl]-6-(3-methyl-3-methylsulfonylbut-1-ynyl)pyridin-3-yl]-1-(2,2,2-trifluoroethyl)indazol-3-yl]-methylsulfonylazanide
InChi Key
SSXPGMNGIORJAQ-PZNXWHLTSA-M
InChi Code
InChI=1S/C39H32ClF10N7O5S2.Na/c1-36(2,63(3,59)60)10-9-21-5-6-22(23-7-8-26(40)30-32(23)57(17-37(43,44)45)54-35(30)55-64(4,61)62)31(51-21)27(13-18-11-19(41)14-20(42)12-18)52-28(58)16-56-34-29(33(53-56)39(48,49)50)24-15-25(24)38(34,46)47;/h5-8,11-12,14,24-25,27H,13,15-17H2,1-4H3,(H2,52,54,55,58);/q;+1/p-1/t24-,25+,27-;/m0./s1
SMILES Code
O=S([N-]C1=NN(CC(F)(F)F)C2=C1C(Cl)=CC=C2C3=CC=C(C#CC(S(=O)(C)=O)(C)C)N=C3[C@@H](NC(CN(N=C4C(F)(F)F)C5=C4[C@@]6([H])C[C@@]6([H])C5(F)F)=O)CC7=CC(F)=CC(F)=C7)(C)=O.[Na+]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 990.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

View History

A-834735

A-834735