CL-197 is a potent anti-HIV agent low cytotoxicity (EC50 = 0.9 nM, CC50 > 100 μM). It also shows potent inhibitory activities on drug resistant and clinical HIV-1 strains. Oral administration of CL-197 to Beagle dogs resulted in high levels of its bioactive form CL-197-TP in peripheral blood mononuclear cells, the HIV-1 target cells, where the resulting triphosphate exhibited a long-term intracellular retention and could prevent HIV-1 infection for an extended time. CL-197 displayed low in vivo toxicity and favorable pharmacokinetics profiles in Sprague-Dawley rats.
MedKoo Cat#: 124467
Name: CL-197
CAS#: N/A
Chemical Formula: C12H11F2N5O3
Exact Mass: 311.0800
Molecular Weight: 311.25
Elemental Analysis: C, 46.31; H, 3.56; F, 12.21; N, 22.50; O, 15.42
The following data is based on the product molecular weight 311.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
