Ezlopitant, also known CJ-11974; is NK1 receptor antagonist. It has antiemetic and antinociceptive effects. Pfizer was developing ezlopitant for the treatment of irritable bowel syndrome but it appears to have been discontinued.
MedKoo Cat#: 124457
Name: Ezlopitant dihydrochloride
CAS#: 223389-63-7 (2HCl)
Chemical Formula: C31H40Cl2N2O
Exact Mass: 526.2500
Molecular Weight: 527.57
Elemental Analysis: C, 70.58; H, 7.64; Cl, 13.44; N, 5.31; O, 3.03
The following data is based on the product molecular weight 527.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
