Dextromethadone (Discontinued) is an antitussive opioid. It is the (S)-enantiomer of methadone. Dextromethadone acts as a N-methyl-D-aspartate NMDA receptor antagonist similar to ketamine. There is now an asymmetric synthesis available to prepare both dextromethadone [S-(+)-methadone] and levomethadone [R-(−)-methadone]. Dextromethadone is discontinued (DEA controlled substance, DEA Schedule II).
MedKoo Cat#: 124447
Name: Dextromethadone HCl
CAS#: 15284-15-8 (HCl)
Chemical Formula: C21H28ClNO
Exact Mass: 345.1900
Molecular Weight: 345.91
Elemental Analysis: C, 72.92; H, 8.16; Cl, 10.25; N, 4.05; O, 4.63
The following data is based on the product molecular weight 345.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
